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Submit ReviewZAPA sulfate
说明： 'Low affinity' GABAA agonist; also GABAA-ρ antagonist
化学名： (Z)-3-[(Aminoiminomethyl)thio]prop-2-enoic acid sulfate
生物活性 for ZAPA sulfate
More potent than either GABA or muscimol as an agonist at low affinity GABAA receptors and is thus a useful ligand to investigate GABA receptors linked to benzodiazepine receptors. Also a GABAA-ρ receptor antagonist.
技术数据 for ZAPA sulfate
| 分子量 | 244.24 |
| 公式 | C4H6N2O2S.H2SO4 |
| 储存 | Store at RT |
| CAS Number | 371962-01-5 |
| PubChem ID | 90479730 |
| InChI Key | UWVNHPNVOMFDHW-ODZAUARKSA-N |
| Smiles | OS(O)(=O)=O.NC(=N)S\C=C/C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for ZAPA sulfate
参考文献 for ZAPA sulfate
参考文献是支持产品生物活性的出版物。
Allan et al (1986) Isothiouronium compounds as γ-aminobutyric acid agonists. Br.J.Pharmacol. 88 379 PMID: 3015310
Holden-Dye and Walker (1988) ZAPA, (Z)-3-[(aminoiminomethyl)thio]-2-propenoic acid hydrochloride, a potent agonist at GABA-receptors on the Ascaris muscle cell. Br.J.Pharmacol. 95 3 PMID: 2851353
Johnston (1996) GABAC receptors: relatively simple transmitter-gated ion channels? TiPS 17 319 PMID: 8885697
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关键词: ZAPA sulfate, ZAPA sulfate supplier, GABAC, antagonists, agonists, low, affinity, GABAA, receptors, Receptors, GABAA-rho, 0180, Tocris Bioscience
1 篇 ZAPA sulfate 的引用文献
引用文献是使用了 Tocris 产品的出版物。 ZAPA sulfate 的部分引用包括：
Asiedu et al (2012) Modulation of spinal GABAergic analgesia by inhibition of chloride extrusion capacity in mice. J Pain 13 546 PMID: 22537560
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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