Zatebradine hydrochloride

Cat. No. 2202 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Blocks hyperpolarization-activated current (I_f)

别名： UL-FS 49

化学名： 3-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one hydrochloride

纯度： ≥98% (HPLC)

引用文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Zatebradine hydrochloride

Zatebradine hydrochloride is a bradycardic agent that produces use-dependent inhibition of hyperpolarization-activated current I_f (HCN channel) in sinoatrial node cells (EC₅₀ = 480 nM) and Purkinje fibres. Displays negative chronotropic activity in isolated guinea pig atria (EC₅₀ of 13.4 μM).

技术数据 for Zatebradine hydrochloride

分子量	493.04
公式	C₂₆H₃₆N₂O₅.HCl
储存	Desiccate at +4°C
纯度	≥98% (HPLC)
CAS Number	91940-87-3
PubChem ID	3045335
InChI Key	ZRNKXJHEQKMWCH-UHFFFAOYSA-N
Smiles	Cl.COC1=CC=C(CCN(C)CCCN2CCC3=C(CC2=O)C=C(OC)C(OC)=C3)C=C1OC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Zatebradine hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	49.3	100

制备储备液 for Zatebradine hydrochloride

以下数据基于产品分子量 493.04。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.03 mL	10.14 mL	20.28 mL
5 mM	0.41 mL	2.03 mL	4.06 mL
10 mM	0.2 mL	1.01 mL	2.03 mL
50 mM	0.04 mL	0.2 mL	0.41 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

产品说明书 for Zatebradine hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Zatebradine hydrochloride

参考文献是支持产品生物活性的出版物。

Van Bogaert et al (1990) Use- and frequency-dependent blockade by UL-FS 49 of the i_f pacemaker current in sheep cardiac Purkinje fibres. Eur.J.Pharmacol. 187 241 PMID: 2272362

Goethals et al (1993) Use-dependent block of the pacemaker current I(f) in rabbit sinoatrial node cells by zatebradine (UL-FS 49). On the mode of action of sinus node inhibitors. Circulation 88 2389 PMID: 8222132

Romanelli et al (2005) Design, synthesis and preliminary biological evaluation of zatebradine analogues as potential blockers of the hyperpolarization-activated current. Bioorg.Med.Chem. 13 1211 PMID: 15670930

If you know of a relevant reference for Zatebradine hydrochloride, please let us know.

按标靶查看相关产品

HCN Channels

按产品操作查看相关产品

查看全部 HCN Channel Blockers

关键词: Zatebradine hydrochloride, Zatebradine hydrochloride supplier, Bradycardic, agent, blocks, If, pacemaker, current, Channel, modulators, VDAC, ULFS49, HCN, blockers, UL-FS, 49, Channels, 2202, Tocris Bioscience

1 篇 Zatebradine hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Zatebradine hydrochloride 的部分引用包括：

Bender et al (2007) Localization of HCN1 channels to presynaptic compartments: novel plasticity that may contribute to hippocampal maturation. J Neurosci 27 4697 PMID: 17460082

您是否知道使用了 Tocris Zatebradine hydrochloride 的优秀论文？请告知我们.