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ZCL 278

Cat. No. 4794 4 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4794 has been discontinued.

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说明： Cdc42 inhibitor
化学名： 2-(4-Bromo-2-chlorophenoxy)-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]thioxomethyl]acetamide
纯度： ≥95% (HPLC)
说明书
引用文献 (4)
评论
生物活性 技术数据 说明书 参考文献

生物活性 for ZCL 278

ZCL 278 is a selective inhibitor of Cdc42. Targets the binding site of the Cdc42 guanine nucleotide exchange factor, intersectin (ITSN). Inhibits Cdc42-mediated cellular effects, including microspike formation in 3T3 fibroblasts and neuronal branching in primary neonatal cortical neurons. Also suppresses cell motility and migration in PC3 cells, without cytotoxic effects.

技术数据 for ZCL 278

分子量 584.89
公式 C21H19BrClN5O4S2
储存 Store at +4°C
纯度 ≥95% (HPLC)
CAS Number 587841-73-4
PubChem ID 1791111
InChI Key XKZDWYDHEBCGCG-UHFFFAOYSA-N
Smiles ClC1=C(OCC(NC(NC2=CC=C(S(NC3=NC(C)=CC(C)=N3)(=O)=O)C=C2)=S)=O)C=CC(Br)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for ZCL 278

参考文献是支持产品生物活性的出版物。

Friesland et al (2013) Small molecule targeting Cdc42-intersectin interaction disrupts Golgi organization and suppresses cell motility. Proc.Natl.Acad.Sci.USA 110 1261 PMID: 23284167

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关键词: ZCL 278, ZCL 278 supplier, ZCL278, Cdc42, Rho, small, GTPases, inhibitors, inhibits, 4794, Tocris Bioscience

4 篇 ZCL 278 的引用文献

引用文献是使用了 Tocris 产品的出版物。 ZCL 278 的部分引用包括：

Speranza et al (2015) Activation of 5-HT7 receptor stimulates neurite elongation through mTOR, Cdc42 and actin filaments dynamics. Nat Biotechnol 9 62 PMID: 25814944

Bijata et al (2017) Synaptic Remodeling Depends on Signaling between Serotonin Receptors and the Extracellular Matrix Cell Rep 19 1767 PMID: 28564597

Speranza et al (2017) Serotonin 5-HT7 receptor increases the density of dendritic spines and facilitates synaptogenesis in forebrain neurons J Neurochem 141 647 PMID: 28122114

Bijata et al (2015) Dystroglycan controls dendritic morphogenesis of hippocampal neurons in vitro. Front Cell Neurosci 9 199 PMID: 26074769

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