ZD 7155 hydrochloride

Cat. No. 1211 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective non-peptide AT₁ antagonist

化学名： 5,7-Diethyl-3,4-dihydro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-one hydrochloride

纯度： ≥98% (HPLC)

引用文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for ZD 7155 hydrochloride

ZD 7155 hydrochloride is a potent and selective competitive antagonist for the angiotensin II type 1 (AT₁) receptor. Displaces [¹²⁵I]-angiotensin II binding with an IC₅₀ value of 3.8 nM in guinea pig adrenal gland membranes. Orally active, and is more potent and longer-acting than the prototype AT₁ antagonist, losartan.

许可信息

Sold with the permission of AstraZeneca UK Ltd.

技术数据 for ZD 7155 hydrochloride

分子量	474.99
公式	C₂₆H₂₆N₆O.HCl
储存	Desiccate at +4°C
纯度	≥98% (HPLC)
CAS Number	146709-78-6
PubChem ID	9826191
InChI Key	NAGGAAHTUXEGFG-UHFFFAOYSA-N
Smiles	Cl.CCC1=CC2=C(CCC(=O)N2CC2=CC=C(C=C2)C2=CC=CC=C2C2=NN=NN2)C(CC)=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ZD 7155 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	4.75	10 温和加热

制备储备液 for ZD 7155 hydrochloride

以下数据基于产品分子量 474.99。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.1 mM	21.05 mL	105.27 mL	210.53 mL
0.5 mM	4.21 mL	21.05 mL	42.11 mL
1 mM	2.11 mL	10.53 mL	21.05 mL
5 mM	0.42 mL	2.11 mL	4.21 mL

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产品说明书 for ZD 7155 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for ZD 7155 hydrochloride

参考文献是支持产品生物活性的出版物。

Junggren et al (1996) Comparative cardiovascular effects of the angiotensin II type 1 receptor antagonists ZD 7155 and los. in the rat. J.Pharm.Pharmacol. 48 829 PMID: 8887734

Veelken et al (1998) Endogenous angiotensin II and the reflex response to stimulation of cardiopulmonary serotonin 5HT₃ receptors. Br.J.Pharmacol. 125 1761 PMID: 9886768

Oldham et al (1993) Zeneca ZD7155: a novel, potent and orally-effective angiotensin II receptor antagonist. Br.J.Pharmacol. 109 P136

If you know of a relevant reference for ZD 7155 hydrochloride, please let us know.

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关键词: ZD 7155 hydrochloride, ZD 7155 hydrochloride supplier, Selective, non-peptide, AT1, antagonists, Receptors, Angiotensin1, ZD7155, hydrochloride, AstraZeneca, Angiotensin, 1211, Tocris Bioscience

2 篇 ZD 7155 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 ZD 7155 hydrochloride 的部分引用包括：

Nostramo et al (2012) Regulation of angiotensin II type 2 receptor gene expression in the adrenal medulla by acute and repeated immobilization stress. Proc Natl Acad Sci U S A 215 291 PMID: 22911895

Leite-Moreira et al (2006) Angiotensin II acutely decreases myocardial stiffness: a novel AT1, PKC and Na+/H+ exchanger-mediated effect. Br J Pharmacol 147 690 PMID: 16415904

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