ZD 7155 hydrochloride

Name: ZD 7155 hydrochloride
Brand: Tocris Bioscience
SKU: 1211

Cat. No. 1211 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1211 has been discontinued.

View all Angiotensin AT<sub>1</sub> Receptors products.

说明： Selective non-peptide AT₁ antagonist

化学名： 5,7-Diethyl-3,4-dihydro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-one hydrochloride

纯度： ≥98% (HPLC)

说明书

引用文献 (2)

生物活性技术数据说明书参考文献

生物活性 for ZD 7155 hydrochloride

ZD 7155 hydrochloride is a potent and selective competitive antagonist for the angiotensin II type 1 (AT₁) receptor. Displaces [¹²⁵I]-angiotensin II binding with an IC₅₀ value of 3.8 nM in guinea pig adrenal gland membranes. Orally active, and is more potent and longer-acting than the prototype AT₁ antagonist, losartan.

许可信息

Sold with the permission of AstraZeneca UK Ltd.

技术数据 for ZD 7155 hydrochloride

分子量	474.99
公式	C₂₆H₂₆N₆O.HCl
储存	Desiccate at +4°C
纯度	≥98% (HPLC)
CAS Number	146709-78-6
PubChem ID	9826191
InChI Key	NAGGAAHTUXEGFG-UHFFFAOYSA-N
Smiles	Cl.CCC1=CC2=C(CCC(=O)N2CC2=CC=C(C=C2)C2=CC=CC=C2C2=NN=NN2)C(CC)=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for ZD 7155 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for ZD 7155 hydrochloride

参考文献是支持产品生物活性的出版物。

Junggren et al (1996) Comparative cardiovascular effects of the angiotensin II type 1 receptor antagonists ZD 7155 and los. in the rat. J.Pharm.Pharmacol. 48 829 PMID: 8887734

Veelken et al (1998) Endogenous angiotensin II and the reflex response to stimulation of cardiopulmonary serotonin 5HT₃ receptors. Br.J.Pharmacol. 125 1761 PMID: 9886768

Oldham et al (1993) Zeneca ZD7155: a novel, potent and orally-effective angiotensin II receptor antagonist. Br.J.Pharmacol. 109 P136

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关键词: ZD 7155 hydrochloride, ZD 7155 hydrochloride supplier, Selective, non-peptide, AT1, antagonists, Receptors, Angiotensin1, ZD7155, hydrochloride, AstraZeneca, Angiotensin, 1211, Tocris Bioscience

2 篇 ZD 7155 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 ZD 7155 hydrochloride 的部分引用包括：

Nostramo et al (2012) Regulation of angiotensin II type 2 receptor gene expression in the adrenal medulla by acute and repeated immobilization stress. Proc Natl Acad Sci U S A 215 291 PMID: 22911895

Leite-Moreira et al (2006) Angiotensin II acutely decreases myocardial stiffness: a novel AT1, PKC and Na+/H+ exchanger-mediated effect. Br J Pharmacol 147 690 PMID: 16415904