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ZE 132

Cat. No. 7533 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective PD-1/PD-L1 interaction inhibitor
化学名： 2-[[[5-Chloro-2-[(5-cyano-3-pyridinyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy]phenyl]methyl][3-(dimethylamino)propyl]amino]ethanesulfonic acid
纯度： ≥98% (HPLC)
说明书
引用文献
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ZE 132

ZE 132 binds to programmed cell death-ligand 1 (PD-L1) with high affinity (KD = 19.36 nM); it potently and selectively inhibits the interaction between programmed cell death-1 (PD-1) and PD-L1 (IC50 = 23.49 nM). ZE 132 promotes CD8+ T cell activation and improves the in vitro cytotoxic killing activity of T-cells. ZE 132 treatment can increase Cxcl9 mRNA expression and lower Tgfb1 mRNA expression in CT26 mouse colorectal cancer model. ZE 132 shows antitumor effects, inhibiting growth of CT26 tumors in mice by 64%.

技术数据 for ZE 132

分子量 721.27
公式 C37H41ClN4O7S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2566710-63-0
PubChem ID 155367962
InChI Key QJSJWFVBDAPNAE-UHFFFAOYSA-N
Smiles CN(CCCN(CC1=C(C=C(C(Cl)=C1)OCC2=CC=CC(C3=CC=C4OCCOC4=C3)=C2C)OCC5=CN=CC(C#N)=C5)CCS(O)(=O)=O)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ZE 132

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 72.13 100

制备储备液 for ZE 132

以下数据基于产品分子量 721.27。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.39 mL 6.93 mL 13.86 mL
5 mM 0.28 mL 1.39 mL 2.77 mL
10 mM 0.14 mL 0.69 mL 1.39 mL
50 mM 0.03 mL 0.14 mL 0.28 mL

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参考文献 for ZE 132

参考文献是支持产品生物活性的出版物。

Liu et al (2021) Discovery of a novel, potent and selective small-molecule inhibitor of PD-1/PD-L1 interaction with robust in vivo anti-tumour efficacy. Br.J.Pharmacol. 178 2651 PMID: 33768523

If you know of a relevant reference for ZE 132, please let us know.

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关键词: ZE 132, ZE 132 supplier, ZE132, potent, selective, inhibitor, inhibits, interaction, between, programmed, cell, death-1, PD-1, death-ligand, 1, PD-L1, promotes, CD8+, T, activation, antitumor, Immune, Checkpoints, 7533, Tocris Bioscience

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