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Zearalenone

Cat. No. 3975 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3975 has been discontinued.

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说明： Estrogen receptor ligand; mycotoxin
化学名： (3S,11E)-3,4,5,6,9,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione
说明书
引用文献 (1)
评论
通路 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for Zearalenone

Zearalenone is a mycotoxin produced by several species of Fusarium fungi. Binds to the estrogen receptor (ER) (IC50 values are 166 and 240 nM for ERβ and ERα respectively) and stimulates the transcriptional activity of both subtypes at concentrations between 1 - 10 nM. Also stimulates growth of T47D breast cancer cells.

技术数据 for Zearalenone

分子量 318.36
公式 C18H22O5
储存 Store at -20°C
CAS Number 17924-92-4
PubChem ID 5281576
InChI Key MBMQEIFVQACCCH-QBODLPLBSA-N
Smiles O=C(C1=C(O)C=C(O)C=C1/C=C/CCC2)O[C@@H](C)CCCC2=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Zearalenone

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Zearalenone

参考文献是支持产品生物活性的出版物。

Kuiper et al (1998) Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β. Endocrinology 139 4252 PMID: 9751507

Khosrokhavar et al (2009) Effects of zearalenone and α-Zearalenol in comparison with ralox. on T47D cells. Toxicol.Mech.Methods 19 246 PMID: 19730705

Takemura et al (2007) Characterization of the estrogenic activities of zearalenone and zeranol in vivo and in vitro. J.Steroid Biochem.Molec.Biol. 103 170

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关键词: Zearalenone, Zearalenone supplier, estrogen, receptor, ER, ligands, mycotoxins, Estrogen, and, Related, Receptors, 3975, Tocris Bioscience

1 篇 Zearalenone 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Zearalenone 的部分引用包括：

Sotnichenko et al (2019) Hydrophobized Reversed-Phase Adsorbent for Protection of Dairy Cattle against Lipophilic Toxins from Diet. Efficiensy in Vitro and in Vivo. Toxins (Basel) 11 PMID: 31067794

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Pathways for Zearalenone

Estrogen Signaling Pathway

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.