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Submit ReviewZinterol hydrochloride
Discontinued Product
1051 has been discontinued.
View all Adrenergic β<sub>2</sub> Receptors products.
说明： Selective β2 agonist
别名： MJ 9184
化学名： N-[5-[2-[(1,1-Dimethyl-2-phenylethyl)amino]-1-hydroxyethyl]-2-hydroxyphenyl]methanesulphonamide hydrochloride
纯度： ≥98% (HPLC)
生物活性 for Zinterol hydrochloride
Zinterol hydrochloride is a potent and selective β2-adrenoceptor agonist (pKB values are 8.3 and < 5.7 for β 2 and β1 receptors respectively, as measured in human artery).
技术数据 for Zinterol hydrochloride
| 分子量 | 414.95 |
| 公式 | C19H26N2O4S.HCl |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 38241-28-0 |
| PubChem ID | 37989 |
| InChI Key | LVNUBJDWJFOMKH-UHFFFAOYSA-N |
| Smiles | OC1=C(NS(=O)(C)=O)C=C(C(O)CNC(C)(C)CC2=CC=CC=C2)C=C1.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Zinterol hydrochloride
参考文献 for Zinterol hydrochloride
参考文献是支持产品生物活性的出版物。
Arvydas Skeberdis et al (1997) Beta-2 adrenergic activation of L-type Ca2+ current in cardiac myocytes. J.Pharmacol.Exp.Ther. 283 452 PMID: 9353357
Hutchinson et al (2006) Agonist effects of zinterol at the mouse and human β3-adrenoceptor. Naunyn Schmiedebergs Arch.Pharmacol. 373 158 PMID: 16601951
Kauman (1997) Four β-adrenoceptor subtypes in the mammalian heart. TiPS 18 70 PMID: 9133774
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关键词: Zinterol hydrochloride, Zinterol hydrochloride supplier, Selective, α2-adrenoceptor, beta2-adrenoceptor, b2-adrenoceptor, β2-adrenergic, α2-adrenergic, beta2-adrenergic, b2-adrenergic, agonists, Receptors, MJ9184, MJ, 9184, Adrenergic, Beta-2, 1051, Tocris Bioscience
4 篇 Zinterol hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Zinterol hydrochloride 的部分引用包括：
Macdougall et al (2012) Caveolae compartmentalise β2-adrenoceptor signals by curtailing cAMP production and maintaining phosphatase activity in the sarcoplasmic reticulum of the adult ventricular myocyte. J Mol Cell Cardiol 52 388 PMID: 21740911
Huang et al (2018) ADRB2 polymorphism Arg16Gly modifies the natural outcome of heart failure and dictates therapeutic response to β-blockers in patients with heart failure. Cell Discov 4 57 PMID: 30374408
Eckle et al (2008) A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice. J Am Coll Cardiol 118 3301 PMID: 18787641
Schutsky et al (2011) Stress and glucocorticoids impair memory retrieval via β2-adrenergic, Gi/o-coupled suppression of cAMP signaling. J Neurosci 31 14172 PMID: 21976502
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.