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ZK 164015

Cat. No. 2183 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2183 has been discontinued.

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说明： Potent estrogen receptor antagonist
化学名： 2-(4-Hydroxyphenyl)-3-methyl-1-[10-(pentylsulfonyl)decyl]-1H-indol-5-ol
纯度： ≥99% (HPLC)
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引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for ZK 164015

ZK 164015 is a potent estrogen receptor silent antagonist. Inhibits 17β-estradiol stimulation of luciferase activity (IC50 = 0.025 μM); potently inhibits the growth of estrogen-sensitive human MCF-7 breast cancer cells in vitro (IC50 ~ 1 nM).

技术数据 for ZK 164015

分子量 513.73
公式 C30H43NO4S
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 177583-70-9
PubChem ID 9806489
InChI Key LYJSJVYJLZOMCD-UHFFFAOYSA-N
Smiles CCCCCS(=O)(=O)CCCCCCCCCCN1C2=CC=C(O)C=C2C(C)=C1C1=CC=C(O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for ZK 164015

参考文献是支持产品生物活性的出版物。

Liu et al (1999) The anti-estrogen hydroxytamoxifen is a potent antagonist in a novel yeast system. Biol.Chem. 380 1341 PMID: 10614829

Walter et al (2004) Synthesis and biological evaluation of stilbene-based pure estrogen antagonists. Bioorg.Med.Chem.Lett. 14 4659 PMID: 15324884

Biberger and von Angerer (1996) 2-Phenylindoles with sulfur containing side chains. Estrogen receptor affinity, antiestrogenic potency, and antitumour activity. J.Steroid Biochem.Molec.Biol. 58 31

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关键词: ZK 164015, ZK 164015 supplier, Potent, estrogen, receptor, antagonists, ER, ERR, Estrogen, Receptors, ZK164015, and, Related, 2183, Tocris Bioscience

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Pathways for ZK 164015

Estrogen Signaling Pathway

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.