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Submit ReviewZK 93426 hydrochloride
说明： Potent and competitive benzodiazepine antagonist
化学名： 4-Methyl-5-(1-methylethoxy)-9H-pyrido[3,4-b]indole-3-carboxylic acid ethyl ester hydrochloride
纯度： ≥99% (HPLC)
生物活性 for ZK 93426 hydrochloride
ZK 93426 hydrochloride is a potent, selective and competitive benzodiazepine receptor antagonist (IC50 values are 0.4 and 0.7 nM for inhibition of [3H]-flunitrazepam binding to rat cerebellum and hippocampus respectively). Similar in vivo profile to flumazenil (Ro 15-1788, Cat No. 1328); produces anxiogenic effects in some behavioral tests and anxiolytic effects in others. Orally active.
技术数据 for ZK 93426 hydrochloride
| 分子量 | 348.82 |
| 公式 | C18H20N2O3.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 1216792-30-1 |
| PubChem ID | 56972167 |
| InChI Key | RNQJDOYVHCISJU-UHFFFAOYSA-N |
| Smiles | Cl.CCOC(=O)C1=C(C)C2=C(NC3=C2C(OC(C)C)=CC=C3)C=N1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for ZK 93426 hydrochloride
参考文献 for ZK 93426 hydrochloride
参考文献是支持产品生物活性的出版物。
Jensen et al (1984) Evaluation of the β-carboline ZK 93 426 as a benzodiazepine receptor antagonist. Psychopharmacology 83 249 PMID: 6089247
Corda et al (1987) Enhancement of γ-aminobutyric acid binding by the anxiolytic β-carbolines ZK 93423 and ZK 91296. J.Neurochem. 48 1355 PMID: 2881979
File and Baldwin (1987) Effects of β-carbolines in animal models of anxiety. Brain Res.Bull. 19 293 PMID: 3315125
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关键词: ZK 93426 hydrochloride, ZK 93426 hydrochloride supplier, Potent, competitive, benzodiazepine, antagonists, GABAA, Receptors, ZK93426, hydrochloride, 1996, Tocris Bioscience
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