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Submit ReviewZolpidem
说明： Benzodiazepine agonist
化学名： N,N,6-Trimethyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetamide
纯度： ≥99% (HPLC)
生物活性 for Zolpidem
Benzodiazepine agonist with high selectivity for α1-subunit-containing GABAA receptors (BZ/ω1 site) and very high intrinsic activity. Ki values are 20, 400 and ≥ 5000 nM for α1-, α2-/α3-, and α5-containing GABAA receptors respectively. Hypnotic that does not induce physical dependence.
技术数据 for Zolpidem
| 分子量 | 307.39 |
| 公式 | C19H21N3O |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 82626-48-0 |
| PubChem ID | 5732 |
| InChI Key | ZAFYATHCZYHLPB-UHFFFAOYSA-N |
| Smiles | O=C(N(C)C)CC1=C(C3=CC=C(C)C=C3)N=C2N1C=C(C)C=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Zolpidem
参考文献 for Zolpidem
参考文献是支持产品生物活性的出版物。
Arbilla et al (1986) High affinity [3H]zolpidem binding in the rat brain: an imidazopyridine with agonist properties at central benzodiazepine receptors. Eur.J.Pharmacol. 130 257 PMID: 2878820
Crestani et al (2000) Mechanism of action of the hypnotic zol. in vivo. Br.J.Pharmacol. 131 1251 PMID: 11090095
Depoortere et al (1986) Zolpidem, a novel nonbenzodiazepine hypnotic. 1. Neuropharmacological and behavioural effects. J.Pharmacol.Exp.Ther. 237 649 PMID: 2871178
Perrault et al (1992) Lack of tolerance and physical dependence upon repeated treatment with the novel hypnotic zol. J.Pharmacol.Exp.Ther. 263 298 PMID: 1403792
Soderhielm et al (2018) Probing the molecular basis for affinity/potency- and efficacy-based subtype-selectivity exhibited by benzodiazepine-site modulators at GABAA receptors. Biochem.Pharmacol. 158 339 PMID: 30121248
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关键词: Zolpidem, Zolpidem supplier, Benzodiazepine, agonists, GABAA, Receptors, 0655, Tocris Bioscience
7 篇 Zolpidem 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Zolpidem 的部分引用包括：
Seifi et al (2014) Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon. Br J Cancer 34 10361 PMID: 25080596
Geracitano et al (2012) Functional expression of the GABA(A) receptor α2 and α3 subunits at synapses between intercalated medial paracapsular neurons of mouse amygdala. Front Neural Circuits 6 32 PMID: 22666188
Letra-Vilela et al (2016) Distinct roles of N-acetyl and 5-methoxy groups in the antiproliferative and neuroprotective effects of melatonin Molecular and Cellular Endocrinology 434 238 PMID: 27402603
Lazarus and Huang (2011) Distinct maturation profiles of perisomatic and dendritic targeting GABAergic interneurons in the mouse primary visual cortex during the critical period of ocular dominance plasticity. J Neurophysiol 106 775 PMID: 21613595
Kotak et al (2008) Hearing loss prevents the maturation of GABAergic transmission in the auditory cortex. J Neurosci 18 2098 PMID: 18222937
Wulff et al (2007) From synapse to behavior: rapid modulation of defined neuronal types with engineered GABAA receptors. Nat Neurosci 10 923 PMID: 17572671
Bowser et al (2002) Altered kinetics and benzodiazepine sensitivity of a GABAA receptor subunit mutation [gamma 2(R43Q)] found in human epilepsy. Proc Natl Acad Sci U S A 99 15170 PMID: 12415111
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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