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说明： Benzodiazepine agonist
化学名： 4-Methyl-1-piperazinecarboxylic acid 6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo[3,4-b] pyrazin-5-yl ester
纯度： ≥99% (HPLC)
生物活性 for Zopiclone
A non benzodiazepine BZR agonist, with little difference in affinity for the BZ1 and BZ2 subtypes; however its CNS effects differ from those of other BZR ligands and this may be due to interaction with a different subunit.
技术数据 for Zopiclone
| 分子量 | 388.81 |
| 公式 | C17H17ClN6O3 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 43200-80-2 |
| PubChem ID | 5735 |
| InChI Key | GBBSUAFBMRNDJC-UHFFFAOYSA-N |
| Smiles | CN1CCN(CC1)C(=O)OC1N(C(=O)C2=NC=CN=C12)C1=CC=C(Cl)C=N1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Zopiclone
参考文献 for Zopiclone
参考文献是支持产品生物活性的出版物。
Goa and Heel (1986) ZopiC.. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy as a hypnotic. Drugs 32 48 PMID: 2874974
Im et al (1993) Potentiation of γ-aminobutyric acid induced chloride currents by various benzodiazepine site agonists with the α1γ2, β2γ2 and α1β2γ2 subtypes of cloned γ-aminobutyric acid type A receptors. Mol.Pharmacol. 44 866 PMID: 7901754
Munakata et al (1996) Heterogeneous distribution of benzodiazepine receptors among rat neostriatal neurones. Br.J.Pharmacol. 118 820 PMID: 8762113
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关键词: Zopiclone, Zopiclone supplier, Benzodiazepine, agonists, GABAA, Receptors, 1094, Tocris Bioscience
1 篇 Zopiclone 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Zopiclone 的部分引用包括：
Petroski et al (2006) Indiplon is a high-affinity positive allosteric modulator with selectivity for alpha1 subunit-containing GABAA receptors. J Pharmacol Exp Ther 317 369 PMID: 16399882
Zopiclone 的评论
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.