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ZZL 7

Cat. No. 7898 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Inhibitor of SERT and nNOS interaction
化学名： N-Acetyl-L-alanyl-L-valine methyl ester
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ZZL 7

ZZL-7 is a fast-acting antidepressant that enhances 5-HT (serotonin) signaling in forebrain circuits. ZZL-7 disrupts the interaction between the 5-HT transporter (SERT) and neuronal nitric oxide synthase (nNOS) in the dorsal raphe nucleus (DRN), reduces extracellular 5-HT concentration and downregulates 5-HT1A receptor auto-activity in the DRN. This reduced auto-inhibition enables increase in firing frequency of serotonergic neurons in the DRN and increases in 5-HT release in the medial hippocampus. ZZL-7 readily crosses the blood-brain barrier.

技术数据 for ZZL 7

分子量 244.29
公式 C11H20N2O4
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 99141-91-0
PubChem ID 166176924
InChI Key RHDUVXUSBMPQOK-CBAPKCEASA-N
Smiles CC(N[C@@H](C)C(N[C@@H](C(C)C)C(OC)=O)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ZZL 7

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
ethanol 24.43 100
DMSO 24.43 100

制备储备液 for ZZL 7

以下数据基于产品分子量 244.29。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.09 mL 20.47 mL 40.93 mL
5 mM 0.82 mL 4.09 mL 8.19 mL
10 mM 0.41 mL 2.05 mL 4.09 mL
50 mM 0.08 mL 0.41 mL 0.82 mL

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参考文献 for ZZL 7

参考文献是支持产品生物活性的出版物。

Sun et al (2022) Design of fast-onset antidepressant by dissociating SERT from nNOS in the DRN. Science 378 390 PMID: 36302033

If you know of a relevant reference for ZZL 7, please let us know.

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关键词: ZZL 7, ZZL 7 supplier, ZZL7, fast-acting, antidepressant, inhibits, inhibitors, interaction, serotonin, transporter, SERT, neuronal, nitric, oxide, synthase, nNOS, 5HT1A, 5-HT1A, depression, 5-HT, Transporters, 7898, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.