Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewLY 2183240
Description: Highly potent anandamide uptake inhibitor; also inhibits FAAH
Chemical Name: 5-[(1,1'-Biphenyl]-4-yl)methyl]-N,N-dimethyl-1H-tetrazole-1-carboxamide
Purity: ≥98% (HPLC)
Biological Activity for LY 2183240
LY 2183240 is a novel and highly potent blocker of anandamide uptake (IC50 = 270 pM). Inhibits fatty acid amide hydrolase (FAAH) activity (IC50 = 12.4 nM). Following i.p. administration in rats, increases brain anandamide concentration and exerts antinociceptive effects in formalin model of pain.
Licensing Information
Sold under license from Eli Lilly and Company
Technical Data for LY 2183240
| M. Wt | 307.35 |
| Formula | C17H17N5O |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 874902-19-9 |
| PubChem ID | 11507802 |
| InChI Key | GZNIYOXWFCDBBJ-UHFFFAOYSA-N |
| Smiles | CN(C)C(=O)N1N=NN=C1CC1=CC=C(C=C1)C1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for LY 2183240
References for LY 2183240
References are publications that support the biological activity of the product.
Dickason-Chesterfield et al (2006) Pharmacological characterization of endocannabinoid transport and fatty acid amide hydrolase inhibitors. Cell Mol.Neurobiol. 26 407 PMID: 16736384
Alexander and Cravat (2006) The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases. J.Am.Chem.Soc. 128 9699 PMID: 16866524
Moore et al (2005) Identification of a high-affinity binding site involved in the transport of endocannabinoids. Proc.Natl.Acad.Sci.USA 102 17852
View Related Products by Target
View Related Products by Product Action
Keywords: LY 2183240, LY 2183240 supplier, FAAH, inhibitors, inhibits, anandamide, reuptake, potent, Anandamide, Amidase, Fatty, Acid, Amide, Hydrolases, AMT, Transporters, cannabinoids, Monoamine, Neurotransmitter, LY2183240, Cannabinoid, Hydrolase, (FAAH), Other, Cannabinoids, 2452, Tocris Bioscience
1 Citation for LY 2183240
Citations are publications that use Tocris products. Selected citations for LY 2183240 include:
Gonzalez-Islas et al (2012) Tonic and transient endocannabinoid regulation of AMPAergic miniature postsynaptic currents and homeostatic plasticity in embryonic motor networks. PLoS One 32 13597 PMID: 23015449
Reviews for LY 2183240
There are currently no reviews for this product. Be the first to review LY 2183240 and earn rewards!
Have you used LY 2183240?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cannabinoid Receptor Ligands Scientific Review
Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.