Opportunities and Perspectives on the Design and Synthesis of PROTAC® Degraders
What is Targeted Protein Degradation?
Targeted Protein Degradation (TPD) broadly refers to strategies that re-...
Read moreTocris Blog
Welcome to the Tocris blog! If you’re looking for fresh insights into new tools for life science research, or are interested in the latest news and events from Tocris then you’re in the right place. Read on to discover our latest content.
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Somatic Instability and Huntington's Disease
What is Huntington’s Disease?
Worldwide people are being diagnosed with the severe, but relatively rare, neurodegenerative disease called...
Read moreDevelopment of a KRAS-Targeting PROTAC
In this question-and-answer session, Michael Bond (Yale University) talks to our Senior Product Specialist, Alex Moloney PhD, about the development of LC 2, a KRAS G12C-targeting PROTAC® which is now available...
Read moreRegenerative Medicine - From Bench to Clinic
In June 2021, BlueRock Therapeutics announced that the first patient had been dosed in a phase I trial of a new cell therapy for the treatment of...
Read moreCerebral Organoids in Neurodevelopment, Neurodegeneration & Virology Research
What are Cerebral Organoids?
Cerebral organoids, also called brain organoids, are miniature organs artificially...
Read moreSARS-CoV-2: An Update on Key Targets, Trends and Discoveries
Since the emergence of SARS-CoV-2 the effort among researchers finding ways to stop the virus has been unprecedented. Huge advances have been made in our knowledge of both the virus (SARS-CoV-2) and associated disease (...
Read moreHow To Use A Bioactive Compound Library
Bioactive compound libraries are composed of small molecules and can be used for high-throughput screening in biomedical research, medicinal chemistry and chemical biology. These screening...
Read moreNew Uses for Organoids
Why Organoids?
The lack of suitable in vitro models that accurately represent specific tissues and disease states is a significant hindrance to basic and translational research. This has led to the development of 3D...
Read moreExisting Drugs Targeting SARS-CoV-2 and Coronaviruses
All Tocris products mentioned in this blog post are for biomedical research use only. They are not intended for human or veterinary use.
The coronavirus family, named for their crown-like shape, cause...
Read moreGMP Ancillary Materials: Importance for Stem Cell Therapy Manufacture
Ancillary Materials for Stem Cell Therapy
Stem cell therapies offer great potential for the treatment of several pathologies, including Parkinson’s disease, diabetes, and heart disease. The...
Read moreROCK Inhibitor for Stem Cell Cryopreservation
The ROCK inhibitor, Y-27632, protects stem cells from dissociation-associated apoptosis during cryopreservation and increases cell viability post-thawing. This blog post discusses why the ROCK inhibitor is required, provides evidence...
Read moreCelebrating 25 Years of Tocris Cookson
Twenty five years ago, Tocris Neuramin and Cookson Chemicals merged to form Tocris Cookson, which remains our trading name to this day. Since then, Tocris has provided the life science community with the latest and most innovative...
Read moredTAG - A Protein Degradation Platform for Target Validation
What is dTAG?
dTAG (degradation TAG) is an innovative approach to target validation, using heterobifunctional small molecule Degraders to harness a cell’s protein degradation system and eliminate a...
Read moreApplications for Epigenetic Chemical Probes in Non-Oncology Research
Epigenetic chemical probes are well established tools in oncology research but their application to other...
Read moreUsing Chemical Probes – A Brief Guide
With such a high level of discussion around the reproducibility of experiments described in the peer-reviewed literature, it is becoming increasingly prudent to scrutinize the tools that we use to conduct our research. Selecting a “good” probe is key to generating reliable and...
Read moreDeveloping Chemical Probes for Epigenetic Targets
The Structural Genomics Consortium (SGC) was set-up in 2004, with the goal of solving the protein structures of relevance to human disease. Since then the mission has expanded to advancing drug discovery via open access...
Read moreTargeting the Immune System in Cancer with Small Molecules
Recent clinical successes in targeting the immune system for the treatment of cancer have harnessed biologicals, including antibodies, proteins, engineered cells and oncolytic viruses. Small molecules directed at the immune system offer advantages over...
Read moreFive Reasons to use Small Molecules in Stem Cell Research
Stem cells are defined by their ability to differentiate into specialized cells and to self-renew. Pluripotent stem cells (PSCs), of which embryonic stem cells (ESCs)...
Read moreSmall Molecules for Neural Induction of Stem Cells
Differentiation of human induced pluripotent stem cells (hiPSCs) into functional neurons is an exciting area of research, with considerable therapeutic potential...
Read moreRAS - The Undruggable Target
Long-termed the “undruggable target”, RAS has recently recaptured the attention of cancer researchers. A new understanding of this target has once again reignited hopes of modulating it to tackle some of the most lethal cancers.
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Read moreNew Fluorescent Dyes for Super-resolution Microscopy
Fluorescence imaging is an essential tool in biological research, which enables the visualization of proteins in live and fixed...
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