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Submit ReviewNCS-382
Description: Antagonist of γ-hydroxybutyric acid
Chemical Name: 6,7,8,9-Tetrahydro-5-hydroxy-5H-benzocyclohept-6-ylideneacetic acid
Purity: ≥99% (HPLC)
Biological Activity for NCS-382
NCS-382 is a γ-Hydroxybutyric acid antagonist, anticonvulsant.
Technical Data for NCS-382
| M. Wt | 218.25 |
| Formula | C13H14O3 |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 520505-01-5 |
| PubChem ID | 5875451 |
| InChI Key | UADPGHINQMWEAG-CSKARUKUSA-N |
| Smiles | OC1C2=C(CCC\C1=C/C(O)=O)C=CC=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for NCS-382
Certificate of Analysis is currently unavailable on-line.
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References for NCS-382
References are publications that support the biological activity of the product.
King et al (1997) Gammahydroxybutyrate (GHB) receptor ligand effects on evoked synaptic field potentials in CA1 of the rat hippocampal slice. J.Neural Transm. 104 1177 PMID: 9503264
Maitre et al (1990) A specific γ-hydroxybutyrate receptor ligand possesses both antagonist and anticonvulsant properties. J.Pharmacol.Exp.Ther. 255 657 PMID: 2173754
Schmidt et al (1991) Anti-sedative and anti-cataleptic properties of NCS-382, a γ-hydroxybutyrate receptor antagonist. Eur.J.Pharmacol. 203 393 PMID: 1773824
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Keywords: NCS-382, NCS-382 supplier, antagonists, γ-hydroxybutyric, gamma-hydroxybutyric, acid, GABAA, GABAC, Receptors, GABAB, anticonvulsant, Miscellaneous, GABA, 0780, Tocris Bioscience
Citations for NCS-382
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Currently there are no citations for NCS-382.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.