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Submit ReviewPiribedil dihydrochloride
Description: Dopamine agonist
Chemical Name: 2-[4-(1,3-Benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine dihydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Piribedil dihydrochloride
Piribedil dihydrochloride is a direct dopamine agonist, in clinical use for treatment of dopaminergic system dysfunction. Recent work suggests that it is selective for the D3 subtype, for which it has 20 times higher affinity than for D2, and possesses no significant affinity for D1 receptors.
Technical Data for Piribedil dihydrochloride
| M. Wt | 371.27 |
| Formula | C16H18N4O2.2HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1451048-94-4 |
| PubChem ID | 3038520 |
| InChI Key | VRSRBPOCDOKYKT-UHFFFAOYSA-N |
| Smiles | Cl.Cl.C(N1CCN(CC1)C1=NC=CC=N1)C1=CC=C2OCOC2=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Piribedil dihydrochloride
References for Piribedil dihydrochloride
References are publications that support the biological activity of the product.
Cagnotto et al (1996) In vitro affinity of piribedil for DA D3 receptor subtypes, an autoradiographic study. Eur.J.Pharmacol. 313 63 PMID: 8905329
Jenne (1992) Parkinson's disease: pathological mechanisms and actions of piribedil. J.Neurol. 239 S2 PMID: 1634907
Offermeier and van Rooyen (1986) A comparative study of the locomotor activity effects of apomor. and the 'atypical DA agonists' (piribedil and S36080). Life Sci. 38 895 PMID: 3081774
Merck Index 12 7648
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Keywords: Piribedil dihydrochloride, Piribedil dihydrochloride supplier, Dopamine, agonist, D2-like, Non-Selective, Receptors, dopaminergic, Non-selective, 1031, Tocris Bioscience
1 Citation for Piribedil dihydrochloride
Citations are publications that use Tocris products. Selected citations for Piribedil dihydrochloride include:
Rodrigues et al (2014) Olfactory impairment in the rotenone model of Parkinson's disease is associated with bulbar DArgic D2 activity after REM sleep deprivation. Front Cell Neurosci 8 383 PMID: 25520618
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.