Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewZAPA sulfate
Description: 'Low affinity' GABAA agonist; also GABAA-ρ antagonist
Chemical Name: (Z)-3-[(Aminoiminomethyl)thio]prop-2-enoic acid sulfate
Biological Activity for ZAPA sulfate
More potent than either GABA or muscimol as an agonist at low affinity GABAA receptors and is thus a useful ligand to investigate GABA receptors linked to benzodiazepine receptors. Also a GABAA-ρ receptor antagonist.
Technical Data for ZAPA sulfate
| M. Wt | 244.24 |
| Formula | C4H6N2O2S.H2SO4 |
| Storage | Store at RT |
| CAS Number | 371962-01-5 |
| PubChem ID | 90479730 |
| InChI Key | UWVNHPNVOMFDHW-ODZAUARKSA-N |
| Smiles | OS(O)(=O)=O.NC(=N)S\C=C/C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for ZAPA sulfate
References for ZAPA sulfate
References are publications that support the biological activity of the product.
Allan et al (1986) Isothiouronium compounds as γ-aminobutyric acid agonists. Br.J.Pharmacol. 88 379 PMID: 3015310
Holden-Dye and Walker (1988) ZAPA, (Z)-3-[(aminoiminomethyl)thio]-2-propenoic acid hydrochloride, a potent agonist at GABA-receptors on the Ascaris muscle cell. Br.J.Pharmacol. 95 3 PMID: 2851353
Johnston (1996) GABAC receptors: relatively simple transmitter-gated ion channels? TiPS 17 319 PMID: 8885697
View Related Products by Target
View Related Products by Product Action
Keywords: ZAPA sulfate, ZAPA sulfate supplier, GABAC, antagonists, agonists, low, affinity, GABAA, receptors, Receptors, GABAA-rho, 0180, Tocris Bioscience
1 Citation for ZAPA sulfate
Citations are publications that use Tocris products. Selected citations for ZAPA sulfate include:
Asiedu et al (2012) Modulation of spinal GABAergic analgesia by inhibition of chloride extrusion capacity in mice. J Pain 13 546 PMID: 22537560
Reviews for ZAPA sulfate
There are currently no reviews for this product. Be the first to review ZAPA sulfate and earn rewards!
Have you used ZAPA sulfate?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.