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Submit ReviewYM 511
Description: Potent aromatase (CYP19) inhibitor
Chemical Name: 4-[[(4-Bromophenyl)methyl]-4H-1,2,4-triazol-4-ylamino]benzonitrile
Purity: ≥99% (HPLC)
Biological Activity for YM 511
YM 511 is an orally active, potent aromatase (CYP19) inhibitor (IC50 values are 0.4 and 0.12 nM at rat ovary and human placenta cells respectively) that only weakly inhibits the synthesis of other steroid hormones. Reduces plasma estrogen levels into ranges induced by ovariectomy and inhibits testosterone-induced breast cancer cell growth in vitro (IC50 = 0.13 nM).
Licensing Information
(Sold with the permission of Astellas Pharma Inc.)
Technical Data for YM 511
| M. Wt | 354.2 |
| Formula | C16H12BrN5 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 148869-05-0 |
| PubChem ID | 177865 |
| InChI Key | GGPPBTSXFROGAE-UHFFFAOYSA-N |
| Smiles | BrC(C=C3)=CC=C3CN(N2C=NN=C2)C1=CC=C(C#N)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for YM 511
References for YM 511
References are publications that support the biological activity of the product.
Okada et al (1996) Studies on aromatase inhibitors I. Synthesis and biological evaulation of 4-amino-4H-1,2,4-triaole derivatives. Chem.Pharm.Bull. 44 1871 PMID: 8904814
Kudoh et al (1995) The potent and selective inhibiton of estrogen production by non-steroidal aromatase inhibitor, YM511. J.Steroid Biochem.Molec.Biol. 54 265
Kudoh et al (1996) Inhibitory effect of a novel non-steroidal aromatase inhibitor, YM511 on the proliferation of MCF-7 human breast cancer cell. J.Steroid Biochem.Molec.Biol. 58 189
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