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Description: HDAC6 inhibitor; inhibits α-tubulin deacetylation
Chemical Name: N-[4-[(2R,4R,6S)-4-[[(4,5-Diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N'-hydroxyoctanediamide
Purity: ≥96% (HPLC)
Biological Activity for Tubacin
Tubacin is a selective inhibitor of HDAC6; inhibits the second deacetylase domain (DD2). Does not inhibit HDAC6 histone deacetylase activity; reversibly inhibits α-tubulin deacetylation. Increases α-tubulin acetylation levels with no effect on histone acetylation or cell cycle progression.
External Portal Information for Tubacin
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of Tubacin is reviewed on the Chemical Probes website.
Technical Data for Tubacin
| M. Wt | 721.86 |
| Formula | C41H43N3O7S |
| Storage | Store at -20°C |
| Purity | ≥96% (HPLC) |
| CAS Number | 1350555-93-9 |
| PubChem ID | 6675804 |
| InChI Key | BHUZLJOUHMBZQY-YXQOSMAKSA-N |
| Smiles | OCC(C=C4)=CC=[C@@]4[C@@H]1C[C@H](CSC2=NC(C6=CC=CC=C6)=C(C5=CC=CC=C5)O2)O[C@H]([C@]3=CC=C(NC(CCCCCCC(NO)=O)=O)C=C3)O1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Tubacin
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.22 | 10 |
Preparing Stock Solutions for Tubacin
The following data is based on the product molecular weight 721.86. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 13.85 mL | 69.27 mL | 138.53 mL |
| 0.5 mM | 2.77 mL | 13.85 mL | 27.71 mL |
| 1 mM | 1.39 mL | 6.93 mL | 13.85 mL |
| 5 mM | 0.28 mL | 1.39 mL | 2.77 mL |
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Product Datasheets for Tubacin
References for Tubacin
References are publications that support the biological activity of the product.
Haggarty et al (2003) Multidimensional chemical genetic analysis of diversity-orientated synthesis-derived deacetylase inhibitors using cell-based assays. Chem.Biol. 10 383 PMID: 12770821
Haggarty et al (2003) Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation. Proc.Natl.Acad.Sci.USA 100 4389 PMID: 12677000
Jiang et al (2008) Direct binding with histone deacetylase 6 mediates the reversible recruitment of parkin to the centrosome. J.Neurosci. 28 12993 PMID: 19036992
If you know of a relevant reference for Tubacin, please let us know.
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Keywords: Tubacin, Tubacin supplier, Tubacin, HDAC, inhibitors, class, II, histone, deacetylase, inhibits, deacetylases, alpha-tubulin, α-tubulin, a-tubulin, acetylation, HDAC6, epigenetics, [537049-40-4], Class, HDACs, 3402, Tocris Bioscience
Citations for Tubacin
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
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