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FERb 033

Cat. No. 3523 Submit a Review Datasheet / COA / SDS

Discontinued Product

3523 has been discontinued.

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Description: Potent and selective ERβ agonist
Chemical Name: 2-Chloro-3'-fluoro-3,4'-dihydroxy-[1,1-biphenyl]-4-carboxaldehyde oxime
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Pathways (1)
Biological Activity Technical Data Datasheets References

Biological Activity for FERb 033

FERb 033 is a potent and selective ERβ receptor agonist (Ki = 7.1 nM, EC50 = 4.8 nM). Displays 62-fold selectivity over ERα.

Technical Data for FERb 033

M. Wt 281.67
Formula C13H9ClFNO3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1111084-78-6
PubChem ID 74429219
InChI Key IEBJACOMZQEPOY-UHFFFAOYSA-N
Smiles OC1=C(/C=N/O)C=CC(C2=CC=C(O)C(F)=C2)=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for FERb 033

References are publications that support the biological activity of the product.

Minutolo et al (2009) Structural evolutions of salicylaldoximes as selective agonists for estrogen receptor β. J.Med.Chem. 52 858 PMID: 19128016

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Keywords: FERb 033, FERb 033 supplier, FERb033, estrogen, ERbeta, ERb, ERβ, receptors, agonists, oestrogen, Estrogen, and, Related, Receptors, 3523, Tocris Bioscience

Citations for FERb 033

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Pathways for FERb 033

Estrogen Signaling Pathway

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.