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Description: L-PGDS inhibitor
Chemical Name: 4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-[4-(2H-tetrazol-5-yl)butyl]-piperidine
Purity: ≥98% (HPLC)
Biological Activity for AT 56
AT 56 is an orally active inhibitor of lipocalin-type prostaglandin D synthase (L-PGDS) (Ki = 75 μM, IC50 = 95 μM). Inhibits the production of PGD2 from PGH2 in vitro, with no effect on PGE2 or PGF2α production.
Compound Libraries for AT 56
AT 56 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for AT 56
| M. Wt | 397.52 |
| Formula | C25H27N5 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 162640-98-4 |
| PubChem ID | 11741525 |
| InChI Key | LQNGMDUIRLSESZ-UHFFFAOYSA-N |
| Smiles | C2(C=CC=C3)=C3/C(C(C=CC=C4)=C4C=C2)=C1CCN(CCCCC5=NNN=N5)CC/1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for AT 56
References for AT 56
References are publications that support the biological activity of the product.
Irikura et al (2009) Biochemical, functional and pharmacological characterization of AT-56, an orally active and selective inhibitor of lipocalin-type prostaglandin D synthase. J.Biol.Chem. 284 7623 PMID: 19131342
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Keywords: AT 56, AT 56 supplier, AT56, L-PGDS, lipocalin-type, prostaglandin, PG, D, synthase, inhibitors, inhibits, Other, Synthases/Synthetases, 3531, Tocris Bioscience
2 Citations for AT 56
Citations are publications that use Tocris products. Selected citations for AT 56 include:
Rhian M et al (2015) Adipocyte Mineralocorticoid Receptor Activation Leads to Metabolic Syndrome and Induction of Prostaglandin D2 Synthase. Hypertension 66 149-57 PMID: 25966493
Jaurena et al (2015) Zic1 controls placode progenitor formation non-cell autonomously by regulating retinoic acid production and transport. Elife 6 7476 PMID: 26101153
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