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Submit ReviewCl-4AS-1
Description: Steroidal androgen receptor agonist
Chemical Name: (4aα,4bβ,6aα,7α,9aβ,9bα,11aβ)-N-(2-Chlorophenyl)-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1,4,6a-trimethyl-2-oxo-1H-indeno[5,4-f]quinoline-7-carboxamide
Purity: ≥99% (HPLC)
Biological Activity for Cl-4AS-1
Cl-4AS-1 is a potent steroidal androgen receptor agonist (IC50 = 12 nM). Mimics the action of 5α-dihydrotestosterone (DHT). Transactivates the mouse mammary tumor virus (MMTV) promoter; represses MMP1 promoter activity. Inhibits 5α-reductase type I and II (IC50 values are 6 and 10 nM respectively).
Technical Data for Cl-4AS-1
| M. Wt | 441.01 |
| Formula | C26H33ClN2O2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 188589-66-4 |
| PubChem ID | 90488881 |
| InChI Key | CTVXDPDUOKQBKZ-BLIBDJTASA-N |
| Smiles | O=C(NC1=CC=CC=C1Cl)[C@H]2CC[C@@]3([H])[C@]4([H])CC[C@@]5([H])N(C)C(C=C[C@]5(C)[C@@]4([H])CC[C@@]32C)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Cl-4AS-1
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.41 | 10 | |
| ethanol | 4.41 | 10 |
Preparing Stock Solutions for Cl-4AS-1
The following data is based on the product molecular weight 441.01. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.68 mL | 113.38 mL | 226.75 mL |
| 0.5 mM | 4.54 mL | 22.68 mL | 45.35 mL |
| 1 mM | 2.27 mL | 11.34 mL | 22.68 mL |
| 5 mM | 0.45 mL | 2.27 mL | 4.54 mL |
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Product Datasheets for Cl-4AS-1
References for Cl-4AS-1
References are publications that support the biological activity of the product.
Tolman et al (1997) 4-Methyl-3-oxo-4-aza-5α-androst-1-ene-17β-N-aryl-carboxamides: an approach to combined androgen blockade [5α-reductase inhibition with androgen receptor binding in vitro]. J.Steroid.Biochem.Mol.Biol. 60 303 PMID: 9219921
Schmidt et al (2009) Identification of anabolic selective androgen receptor modulators with reduced activities in reproductive tissues and sebaceous glands. J.Biol.Chem. 284 36367 PMID: 19846549
If you know of a relevant reference for Cl-4AS-1, please let us know.
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Keywords: Cl-4AS-1, Cl-4AS-1 supplier, steroidal, androgen, receptors, agonists, Cl-4AS-1, Cl4AS1, transactivates, MMTV, inhibits, 5alpha, 5α, 5a, reductases, inhibitors, Androgen, Receptor, Other, Reductase, 3812, Tocris Bioscience
1 Citation for Cl-4AS-1
Citations are publications that use Tocris products. Selected citations for Cl-4AS-1 include:
Sarah I et al (2021) Cell-Based Bioassay to Screen Environmental Chemicals and Human Serum for Total Glucocorticogenic Activity. Environ Toxicol Chem 40 177-186 PMID: 33085113
Do you know of a great paper that uses Cl-4AS-1 from Tocris? Please let us know.
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