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Description: Selective androgen receptor modulator (SARM)
Chemical Name: (1S,3aS,3bS,5aR,9aR,9bS,11aS)-6,9a,11a-Trimethyl-7-oxo-N-[2-(trifluoromethyl)phenyl]-2,3,3a,3b,4,5,5a,9b,10,11-decahydro-1H-indeno[5,4-f]quinoline-1-carboxamide
Purity: ≥98% (HPLC)
Biological Activity for TFM-4AS-1
TFM-4AS-1 is a potent selective androgen receptor modulator (SARM) (IC50 = 30 nM). Steroidal compound. Exhibits limited effects on reproductive tissues and sebaceous glands; does not repress AP-1-sensitive MMP-1 reporter. Inhibits 5α-reductase type I and II (IC50 values are 2 and 3 nM respectively).
Technical Data for TFM-4AS-1
| M. Wt | 474.56 |
| Formula | C27H33F3N2O2 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 188589-61-9 |
| PubChem ID | 10277123 |
| InChI Key | YFBLEKKYWFJKBP-JZFZSVFHSA-N |
| Smiles | O=C1C=C[C@@]2(C)[C@](CC[C@]3([H])[C@@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@@H]4[C@@](NC5=C(C(F)(F)F)C=CC=C5)=O)([H])N1C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TFM-4AS-1
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.75 | 10 | |
| ethanol | 4.75 | 10 |
Preparing Stock Solutions for TFM-4AS-1
The following data is based on the product molecular weight 474.56. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.07 mL | 105.36 mL | 210.72 mL |
| 0.5 mM | 4.21 mL | 21.07 mL | 42.14 mL |
| 1 mM | 2.11 mL | 10.54 mL | 21.07 mL |
| 5 mM | 0.42 mL | 2.11 mL | 4.21 mL |
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Product Datasheets for TFM-4AS-1
References for TFM-4AS-1
References are publications that support the biological activity of the product.
Schmidt et al (2009) Identification of anabolic selective androgen receptor modulators with reduced activities in reproductive tissues and sebaceous glands. J.Biol.Chem. 284 36367 PMID: 19846549
If you know of a relevant reference for TFM-4AS-1, please let us know.
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Keywords: TFM-4AS-1, TFM-4AS-1 supplier, selective, androgen, receptor, modulator, AR, ligand, SARM, receptors, Androgen, Receptor, Other, Reductase, 3813, Tocris Bioscience
1 Citation for TFM-4AS-1
Citations are publications that use Tocris products. Selected citations for TFM-4AS-1 include:
Jennifer J et al (2020) Predicting the Activation of the Androgen Receptor by Mixtures of Ligands Using Generalized Concentration Addition. Toxicol Sci 177 466-475 PMID: 32726424
Do you know of a great paper that uses TFM-4AS-1 from Tocris? Please let us know.
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