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Submit ReviewTCS 1205
Description: GABAA agonist; displays subtype selectivity
Chemical Name: 5-Nitro-α-oxo-N-(1R)-phenylethyl]-1H-indole-3-acetamide
Purity: ≥99% (HPLC)
Biological Activity for TCS 1205
GABAA α2 agonist and GABAA α1 partial agonist in vitro (Ki values are 14 and 121 nM respectively). Exhibits non-sedative anxiolytic activity in vivo.
Technical Data for TCS 1205
| M. Wt | 337.33 |
| Formula | C18H15N3O4 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 355022-97-8 |
| PubChem ID | 10315001 |
| InChI Key | VCKKJKQZHHPPDR-LLVKDONJSA-N |
| Smiles | O=C(C(N[C@H](C)C3=CC=CC=C3)=O)C2=CNC1=CC=C([N+]([O-])=O)C=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TCS 1205
References for TCS 1205
References are publications that support the biological activity of the product.
Primofiore et al (2001) Novel N-(arylalkyl)indol-3-ylglyoxylamides targeted as ligands of the benzodiazepine receptor: synthesis, biological evaluation, and molecular modeling analysis of the structure-activity relationships. J.Med.Chem. 44 2286 PMID: 11428922
Taliani et al (2009) Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the γ-aminobutyric acid-A (GABAA) κ2 benzodiazepine receptor. J.Med.Chem. 52 3723 PMID: 19469479
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Keywords: TCS 1205, TCS 1205 supplier, TCS1205, GABAA, receptors, subtype-selective, Receptors, 3941, Tocris Bioscience
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.