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Submit ReviewZearalenone
Description: Estrogen receptor ligand; mycotoxin
Chemical Name: (3S,11E)-3,4,5,6,9,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione
Biological Activity for Zearalenone
Zearalenone is a mycotoxin produced by several species of Fusarium fungi. Binds to the estrogen receptor (ER) (IC50 values are 166 and 240 nM for ERβ and ERα respectively) and stimulates the transcriptional activity of both subtypes at concentrations between 1 - 10 nM. Also stimulates growth of T47D breast cancer cells.
Technical Data for Zearalenone
| M. Wt | 318.36 |
| Formula | C18H22O5 |
| Storage | Store at -20°C |
| CAS Number | 17924-92-4 |
| PubChem ID | 5281576 |
| InChI Key | MBMQEIFVQACCCH-QBODLPLBSA-N |
| Smiles | O=C(C1=C(O)C=C(O)C=C1/C=C/CCC2)O[C@@H](C)CCCC2=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Zearalenone
References for Zearalenone
References are publications that support the biological activity of the product.
Kuiper et al (1998) Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β. Endocrinology 139 4252 PMID: 9751507
Khosrokhavar et al (2009) Effects of zearalenone and α-Zearalenol in comparison with ralox. on T47D cells. Toxicol.Mech.Methods 19 246 PMID: 19730705
Takemura et al (2007) Characterization of the estrogenic activities of zearalenone and zeranol in vivo and in vitro. J.Steroid Biochem.Molec.Biol. 103 170
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Keywords: Zearalenone, Zearalenone supplier, estrogen, receptor, ER, ligands, mycotoxins, Estrogen, and, Related, Receptors, 3975, Tocris Bioscience
1 Citation for Zearalenone
Citations are publications that use Tocris products. Selected citations for Zearalenone include:
Sotnichenko et al (2019) Hydrophobized Reversed-Phase Adsorbent for Protection of Dairy Cattle against Lipophilic Toxins from Diet. Efficiensy in Vitro and in Vivo. Toxins (Basel) 11 PMID: 31067794
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Pathways for Zearalenone
