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Dynole 34-2

Cat. No. 4222 4 Citations Submit a Review Datasheet / COA / SDS
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Description: Dynamin I inhibitor
Chemical Name: 2-Cyano-3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-N-octyl-2-propenamide
Purity: ≥99% (HPLC)
Datasheet
Citations (4)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Dynole 34-2

Dynole 34-2 is a dynamin I inhibitor (IC50 = 1.3 μM). Inhibits receptor-mediated endocytosis (RME) (IC50 = 5.0 μM).

Compound Libraries for Dynole 34-2

Dynole 34-2 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Dynole 34-2

M. Wt 408.58
Formula C25H36N4O
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1128165-88-7
PubChem ID 44157463
InChI Key MYIMRONQBLZJFI-DYTRJAOYSA-N
Smiles CN(C)CCCN2C1=CC=CC=C1C(/C=C(C(NCCCCCCCC)=O)\C#N)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Dynole 34-2

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.86 100
ethanol 20.43 50

Preparing Stock Solutions for Dynole 34-2

The following data is based on the product molecular weight 408.58. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.45 mL 12.24 mL 24.48 mL
5 mM 0.49 mL 2.45 mL 4.9 mL
10 mM 0.24 mL 1.22 mL 2.45 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

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References for Dynole 34-2

References are publications that support the biological activity of the product.

Hill et al (2009) Inhibition of dynamin mediated endocytosis by the dynoles - synthesis and functional activity of a family of indoles. J.Med.Chem. 52 3762 PMID: 19459681

Hill et al (2010) Iminochromene inhibitors of dynamins I and II GTPase activity and endocytosis. J.Med.Chem. 53 4094 PMID: 20426422

If you know of a relevant reference for Dynole 34-2, please let us know.

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Keywords: Dynole 34-2, Dynole 34-2 supplier, dynamin, I, inhibitors, inhibits, gtpases, rme, receptor-mediated, endocytosis, Dynamin, 4222, Tocris Bioscience

4 Citations for Dynole 34-2

Citations are publications that use Tocris products. Selected citations for Dynole 34-2 include:

Henri J et al (2014) Multiplex assay for live-cell monitoring of cellular fates of amyloid-β precursor protein (APP). PLoS One 9 e98619 PMID: 24932508

Alisha et al (2022) Chronic neurotransmission increases the susceptibility of lateral-line hair cells to ototoxic insults. Elife 11 PMID: 36047587

Lasic (2017) Dynamin regulates the fusion pore of endo- and exocytotic vesicles as revealed by membrane capacitance measurements. Biochim Biophys Acta 1861 2293 PMID: 28669852

Han et al (2015) Combining valosin-containing protein (VCP) inhibition and suberanilohydroxamic acid (SAHA) treatment additively enhances the folding, trafficking, and function of epilepsy-associated γ-aminobutyric acid, type A (GABAA) receptors. Am J Physiol Cell Physiol 290 325 PMID: 25406314

Do you know of a great paper that uses Dynole 34-2 from Tocris? Please let us know.

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