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BAY 41-2272

Cat. No. 4430 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Soluble guanylyl cyclase (sGC) activator
Chemical Name: 5-Cyclopropyl-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-pyrimidinamine
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for BAY 41-2272

BAY 41-2272 is an activator of soluble guanylyl cyclase (sGC); acts at a nitric oxide (NO)-independent regulatory site in the sGC α1 subunit. Inhibits platelet aggregation (IC50 = 36 nM) and phenylephrine-induced contractions of rabbit aorta (IC50 = 0.30 μM). Also reduces vascular smooth muscle growth through cAMP- and cGMP-dependent PKA and PKG pathways.

Compound Libraries for BAY 41-2272

BAY 41-2272 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for BAY 41-2272

M. Wt 360.39
Formula C20H17FN6
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 256376-24-6
PubChem ID 9798973
InChI Key ATOAHNRJAXSBOR-UHFFFAOYSA-N
Smiles FC(C=CC=C3)=C3CN2N=C(C4=NC=C(C5CC5)C(N)=N4)C1=CC=CN=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BAY 41-2272

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.04 100

Preparing Stock Solutions for BAY 41-2272

The following data is based on the product molecular weight 360.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.77 mL 13.87 mL 27.75 mL
5 mM 0.55 mL 2.77 mL 5.55 mL
10 mM 0.28 mL 1.39 mL 2.77 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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Product Datasheets for BAY 41-2272

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for BAY 41-2272

References are publications that support the biological activity of the product.

Stasch et al (2010) NO-independent regulatory site on soluble guanylate cyclase. Nature 410 212 PMID: 11242081

Joshi et al (2011) The soluble guanylate cyclase stimulator BAY 41-2272 inhibits vascular smooth muscle growth through the cAMP-dependent protein kinase and cGMP-dependent protein kinase pathways. J.Pharmacol.Exp.Ther. 339 394 PMID: 21825001

Mittendorf et al (2009) Discovery of Riociguat (BAY 63-2521): a potent, oral stimulator of soluble guanylate cyclase for the treatment of pulmonary hypertension. ChemMedChem 4 853 PMID: 19263460

If you know of a relevant reference for BAY 41-2272, please let us know.

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Keywords: BAY 41-2272, BAY 41-2272 supplier, activators, soluble, guanylyl, guanylate, cyclases, sGC, BAY41-2272, Guanylyl, Cyclase, Other, Nitric, Oxide, Enzyme, Substrates, /, Activators, 4430, Tocris Bioscience

1 Citation for BAY 41-2272

Citations are publications that use Tocris products. Selected citations for BAY 41-2272 include:

Aly et al (2019) Endothelial Sash1 Is Required for Lung Maturation through Nitric Oxide Signaling. Cell Rep 27 1769-1780.e4 PMID: 31067462

Do you know of a great paper that uses BAY 41-2272 from Tocris? Please let us know.

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