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Submit ReviewLu AA 47070
Discontinued Product
4783 has been discontinued.
View all Adenosine A<sub>2A</sub> Receptors products.
Description: Prodrug of a potent and selective adenosine A2A receptor antagonist
Chemical Name: 4-[(3,3-Dimethyl-1-oxobutyl)amino]-3,5-difluoro-N-[3-[(phosphonooxy)methyl]-2(3H)-thiazolylidene]benzamide
Purity: ≥98% (HPLC)
Biological Activity for Lu AA 47070
Prodrug of a potent and selective adenosine A2A receptor antagonist (Ki values are 5.9, 260, 410 and <10,000 nM for A2A, A2B, A1 and A3 receptors respectively. Reverses parkinsonian motor impairment and motivational effects produced by dopamine D2 receptor blockade in rats. Orally bioavailable.
Technical Data for Lu AA 47070
| M. Wt | 463.39 |
| Formula | C17H20F2N3O6PS |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 913842-25-8 |
| PubChem ID | 11947802 |
| InChI Key | MSWIQSFUBYCFJE-UHFFFAOYSA-N |
| Smiles | FC1=C(NC(CC(C)(C)C)=O)C(F)=CC(C(/N=C2\SC=CN2COP(O)(O)=O)=O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Lu AA 47070
References for Lu AA 47070
References are publications that support the biological activity of the product.
Sams et al (2011) Discovery of phosphoric acid mono-{2-[(E/Z)-4-(3,3-dimethyl-butyrylamino)-3,5-difluoro-benzoylimino]-thiazol-3-ylmethyl} ester (Lu AA47070): a phosphonooxymethylene prodrug of a potent and selective hA2A receptor antagonist. J.Med.Chem. 54 751 PMID: 21210664
Collins et al (2012) The novel adenosine A2A antagonist Lu AA47070 reverses the motor and motivational effects produced by DA D2 receptor blockade. Pharmacol.Biochem.Behav. 100 498 PMID: 22037410
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Keywords: Lu AA 47070, Lu AA 47070 supplier, LuAA47070, prodrug, potent, selective, adenosine, A2A, receptors, antagonists, parkinson's, disease, antiparkinson, parkinsonian, orally, bioavailable, Adenosine, Receptors, 4783, Tocris Bioscience
Citations for Lu AA 47070
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Currently there are no citations for Lu AA 47070.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.