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Submit ReviewZCL 278
Description: Cdc42 inhibitor
Chemical Name: 2-(4-Bromo-2-chlorophenoxy)-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]thioxomethyl]acetamide
Purity: ≥95% (HPLC)
Biological Activity for ZCL 278
ZCL 278 is a selective inhibitor of Cdc42. Targets the binding site of the Cdc42 guanine nucleotide exchange factor, intersectin (ITSN). Inhibits Cdc42-mediated cellular effects, including microspike formation in 3T3 fibroblasts and neuronal branching in primary neonatal cortical neurons. Also suppresses cell motility and migration in PC3 cells, without cytotoxic effects.
Technical Data for ZCL 278
| M. Wt | 584.89 |
| Formula | C21H19BrClN5O4S2 |
| Storage | Store at +4°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 587841-73-4 |
| PubChem ID | 1791111 |
| InChI Key | XKZDWYDHEBCGCG-UHFFFAOYSA-N |
| Smiles | ClC1=C(OCC(NC(NC2=CC=C(S(NC3=NC(C)=CC(C)=N3)(=O)=O)C=C2)=S)=O)C=CC(Br)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for ZCL 278
References for ZCL 278
References are publications that support the biological activity of the product.
Friesland et al (2013) Small molecule targeting Cdc42-intersectin interaction disrupts Golgi organization and suppresses cell motility. Proc.Natl.Acad.Sci.USA 110 1261 PMID: 23284167
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Keywords: ZCL 278, ZCL 278 supplier, ZCL278, Cdc42, Rho, small, GTPases, inhibitors, inhibits, 4794, Tocris Bioscience
4 Citations for ZCL 278
Citations are publications that use Tocris products. Selected citations for ZCL 278 include:
Speranza et al (2015) Activation of 5-HT7 receptor stimulates neurite elongation through mTOR, Cdc42 and actin filaments dynamics. Nat Biotechnol 9 62 PMID: 25814944
Bijata et al (2017) Synaptic Remodeling Depends on Signaling between Serotonin Receptors and the Extracellular Matrix Cell Rep 19 1767 PMID: 28564597
Speranza et al (2017) Serotonin 5-HT7 receptor increases the density of dendritic spines and facilitates synaptogenesis in forebrain neurons J Neurochem 141 647 PMID: 28122114
Bijata et al (2015) Dystroglycan controls dendritic morphogenesis of hippocampal neurons in vitro. Front Cell Neurosci 9 199 PMID: 26074769
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