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Submit ReviewRuBi-Dopa
Description: Caged dopamine; exhibits two-photon sensitivity
Chemical Name: (bis(2,2'-Bipyridine-N,N')trimethylphosphine)-(S)-(3,4-Dihydroxyphenyl)ethylamino ruthenium(2+) dichloride complex
Biological Activity for RuBi-Dopa
RuBi-caged dopamine (Cat. No. 3548); exhibits two-photon sensitivity. Enables non-invasive, optical activation of dopamine receptors with the spatial resolution of a single dendritic spine. Does not display phototoxicity at a concentration of 300 μM.
Licensing Information
Sold under licence from Columbia University
Technical Data for RuBi-Dopa
| M. Wt | 713.6 |
| Formula | C31H36Cl2N5O2PRu |
| Storage | Store at -20°C |
| PubChem ID | 90488992 |
| InChI Key | FPJFHIJODNWCIM-UHFFFAOYSA-L |
| Smiles | [Cl-].[Cl-].[Ru++].CP(C)C.NCCC1=CC=C(O)C(O)=C1.C1=CN=C(C=C1)C1=CC=CC=N1.C1=CC=C(N=C1)C1=CC=CC=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for RuBi-Dopa
References for RuBi-Dopa
References are publications that support the biological activity of the product.
Araya et al (2013) Two-photon optical interrogation of individual dendritic spines with caged DA. ACS Chem. Neurosci. [Epub ahead of print] PMID: 23672485
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Keywords: RuBi-Dopa, RuBi-Dopa supplier, caged, dopamine, two, photon, sensitive, sensitivity, microscopy, dopaminergic, neurons, high, resolution, dendritic, spines, Non-selective, Dopamine, Caged, Compounds, 4932, Tocris Bioscience
Citations for RuBi-Dopa
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Currently there are no citations for RuBi-Dopa.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.