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RHPS 4 methosulfate

Cat. No. 5311 Submit a Review Datasheet / COA / SDS
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Description: Telomerase inhibitor
Chemical Name: 3,11-Difluoro-6,8,13-trimethylquino[4,3,2-kl]acridinium methylsulfate
Purity: ≥98% (HPLC)
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for RHPS 4 methosulfate

RHPS 4 methosulfate is a telomerase inhibitor. Inhibits growth of medulloblastoma and glioblastoma cells in vitro. Induces telomere injury and apoptosis, and reduces growth in CG5 breast cancer cell xenografts in mice. Sensitizes radiation resistant glioblastoma cell lines to radiation.

Technical Data for RHPS 4 methosulfate

M. Wt 458.48
Formula C22H17F2N2.CH3O4S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 390362-78-4
PubChem ID 9804187
InChI Key VRWGYMXWYZBBGF-UHFFFAOYSA-M
Smiles C[N+]4=C2C3=C(C=C(C)C=C3C5=C4C=CC(F)=C5)N(C)C1=CC=C(F)C=C12.COS(=O)([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for RHPS 4 methosulfate

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 4.58 10 with gentle warming
DMSO 9.17 20

Preparing Stock Solutions for RHPS 4 methosulfate

The following data is based on the product molecular weight 458.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 10.91 mL 54.53 mL 109.06 mL
1 mM 2.18 mL 10.91 mL 21.81 mL
2 mM 1.09 mL 5.45 mL 10.91 mL
10 mM 0.22 mL 1.09 mL 2.18 mL

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Product Datasheets for RHPS 4 methosulfate

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for RHPS 4 methosulfate

References are publications that support the biological activity of the product.

Lagah et al (2014) RHPS4 G-quadruplex ligand induces anti-proliferative effects in brain tumor cells. PLoS One 9 e86187 PMID: 24454961

Salvati et al (2007) Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect. J.Clin.Invest. 117 3236 PMID: 17932567

Phatak et al (2007) Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism. Br.J.Cancer 96 1223 PMID: 17406367

Berardinelli et al (2015) The G-quadruplex-stabilising agent RHPS4 induces telomeric dysfunction and enhances radiosensitivity in glioblastoma cells. DNA Repair (Amst.) 25 104 PMID: 25467559

If you know of a relevant reference for RHPS 4 methosulfate, please let us know.

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Citations for RHPS 4 methosulfate

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