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Submit ReviewRoxindole hydrochloride
Description: Dopamine D2 autoreceptor agonist. Also has affinity for D3, D4, 5-HT1A receptors and the 5-HT transporter
Alternative Names: EMD 49980
Chemical Name: 3-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-1H-indol-5-ol hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for Roxindole hydrochloride
Roxindole hydrochloride is a dopamine D2 autoreceptor agonist, with affinity for D3, D4 and 5-HT1 receptors (pKi values are 8.55, 8.93, 8.23, 9.42, 6.00 and 7.05 for human D2, D3, D4, 5-HT1A, 5-HT1B and 5-HT1D receptors). Inhibits 5-HT uptake and is antidepressant in vivo.
Technical Data for Roxindole hydrochloride
| M. Wt | 382.93 |
| Formula | C23H26N2O.HCl |
| Storage | Desiccate at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 108050-82-4 |
| PubChem ID | 9886286 |
| InChI Key | ZCEPVNSWLLJECX-UHFFFAOYSA-N |
| Smiles | OC(C=C4)=CC1=C4NC=C1CCCCN2CCC(C3=CC=CC=C3)=CC2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Roxindole hydrochloride
References for Roxindole hydrochloride
References are publications that support the biological activity of the product.
Bartoszyk et al (1996) Roxindole: psychopharmacological profile of a DA D2 autoreceptor agonist. J.Pharmacol.Exp.Ther. 276 41 PMID: 8558454
Newman-Tancredi et al (1999) Actions of roxindole at recombinant human DA D2, D3 and D4 and serotonin 5-HT1A, 5-HT1B and 5-HT1D receptors. Naunyn Schmiedebergs Arch.Pharmacol. 359 447 PMID: 10431754
Seyfried et al (1989) Biochemical and functional studies on EMD 49980: a potent, selectively presynaptic D-2 DA agonist with actions on serotonin systems. Eur.J.Pharmacol. 160 31 PMID: 2565817
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.