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Submit ReviewUMB 68
Description: GHB receptor ligand
Chemical Name: Sodium 4-Hydroxy-4methylpentanoate
Biological Activity for UMB 68
UMB 68 is a GHB receptor ligand. Exhibits similar receptor afffinity as GHB (IC50 for displacement of 3[H]NCS-382 from GHB receptors is 38 μM compared with 25 μM for GHB). Demonstrates no significant affinity for GABAB receptors and does not exhibit GHB-like behavioral effects in vivo.
Technical Data for UMB 68
| M. Wt | 154.14 |
| Formula | C6H11NaO3 |
| Storage | Desiccate at RT |
| CAS Number | 581099-89-0 |
| PubChem ID | 57340483 |
| InChI Key | RKKDHFJDHVHVLY-UHFFFAOYSA-M |
| Smiles | O=C(CCC(C)(O)C)O[Na] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for UMB 68
References for UMB 68
References are publications that support the biological activity of the product.
Wu et al (2003) A tertiary alcohol analog of γ-hydroxybutyric acid as a specific γ-hydroxybutyric acid receptor ligand. J.Pharmacol.Exp.Ther. 305 675 PMID: 12606613
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Citations for UMB 68
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Currently there are no citations for UMB 68.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.