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Submit Review(±)-ADX 71743
Description: Negative allosteric modulator of mGlu7 receptors; brain penetrant
Chemical Name: 6-(2,4-Dimethylphenyl)-2-ethyl-6,7-dihydro-4(5H)-benzoxazolone
Purity: ≥98% (HPLC)
Biological Activity for (±)-ADX 71743
(±)-ADX 71743 is a negative allosteric modulator at mGlu7 (IC50 = 300 nM). Blocks high frequency-induced LTP at SC-CA1 synapses in hippocampal slices in vitro. Increases evoked excitatory postsynaptic currents (eEPSCs) in mice. Brain penetrant.
Compound Libraries for (±)-ADX 71743
(±)-ADX 71743 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for (±)-ADX 71743
| M. Wt | 269.34 |
| Formula | C17H19NO2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1431641-29-0 |
| PubChem ID | 53391766 |
| InChI Key | CPKZCQHJDFSOJT-UHFFFAOYSA-N |
| Smiles | CC(C=C1C)=CC=C1C(CC2=C3N=C(CC)O2)CC3=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for (±)-ADX 71743
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.93 | 100 | |
| ethanol | 26.93 | 100 |
Preparing Stock Solutions for (±)-ADX 71743
The following data is based on the product molecular weight 269.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.71 mL | 18.56 mL | 37.13 mL |
| 5 mM | 0.74 mL | 3.71 mL | 7.43 mL |
| 10 mM | 0.37 mL | 1.86 mL | 3.71 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.74 mL |
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Product Datasheets for (±)-ADX 71743
References for (±)-ADX 71743
References are publications that support the biological activity of the product.
Klar et al (2015) Activation of metabotropic glutamate receptor 7 is required for induction of long-term potentiation at SC-CA1 synapses in the hippocampus. J.Neurosci. 35 7600 PMID: 25972184
Tassin et al (2016) Phasic and tonic mGlu7 receptor activity modulates the thalamocortical network. Front Neural Circuits 10 31 PMID: 27199672
If you know of a relevant reference for (±)-ADX 71743, please let us know.
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Keywords: (±)-ADX 71743, (±)-ADX 71743 supplier, (±)-ADX, 71743, potent, negative, allosteric, modulators, NAMs, mGlu7, receptors, metabotropic, glutamate, epilepsy, 1431641-29-0, Glutamate, (Metabotropic), Group, III, Receptors, 5715, Tocris Bioscience
1 Citation for (±)-ADX 71743
Citations are publications that use Tocris products. Selected citations for (±)-ADX 71743 include:
Harold D et al (2022) Subsynaptic mobility of presynaptic mGluR types is differentially regulated by intra- and extracellular interactions. Mol Biol Cell 33 ar66 PMID: 35511883
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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