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Submit ReviewK-(D-1-Nal)-FwLL-NH2
Description: High affinity and potent ghrelin receptor inverse agonist
Biological Activity for K-(D-1-Nal)-FwLL-NH2
K-(D-1-Nal)-FwLL-NH2 is a high affinity and potent ghrelin receptor inverse agonist (Ki values are 4.9 and 31 nM in COS7 and HEK293T cells, respectively). Blocks ghrelin receptor-mediated Gq- and G13-dependent signaling pathways.
Technical Data for K-(D-1-Nal)-FwLL-NH2
| M. Wt | 902.13 |
| Formula | C51H67N9O6 |
| Sequence |
KXFWLL (Modifications: X=D-1-Nal,Trp-4 = D-Trp, Leu-6 = C-terminal amide) |
| Storage | Store at -20°C |
| CAS Number | 1394288-22-2 |
| PubChem ID | 71453489 |
| InChI Key | NCMQVOQOKBIHPA-MHRDGXECSA-N |
| Smiles | [H]N[C@@H](CCCCN)C(=O)N[C@H](CC1=CC=CC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for K-(D-1-Nal)-FwLL-NH2
References for K-(D-1-Nal)-FwLL-NH2
References are publications that support the biological activity of the product.
Els et al (2012) An aromatic region to induce a switch between agonism and inverse agonism at the ghrelin receptor. J.Med.Chem. 55 7437 PMID: 22920150
M'Kadmi et al (2015) Agonism, antagonism, and inverse agonism bias at the ghrelin receptor signaling. J.Biol.Chem. 290 27021 PMID: 26363071
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Keywords: K-(D-1-Nal)-FwLL-NH2, K-(D-1-Nal)-FwLL-NH2 supplier, ghrelin, receptors, inverse, agonists, agonism, peptide, potent, high, affinity, Ghrelin, Receptors, 5830, Tocris Bioscience
Citations for K-(D-1-Nal)-FwLL-NH2
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Currently there are no citations for K-(D-1-Nal)-FwLL-NH2.
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Literature in this Area
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.