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Submit ReviewEC 19
Description: Synthetic retinoid; induces differentiation of stem cells
Chemical Name: 3-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl]benzoic acid
Purity: ≥98% (HPLC)
Biological Activity for EC 19
EC 19 is a synthetic analogue of all trans-retinoic acid. Promotes differentiation of human embryonal carcinoma (EC) cells primarily into epithelial-like cells, along with a small number of neurons.
Compound Libraries for EC 19
EC 19 is also offered as part of the Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.
Technical Data for EC 19
| M. Wt | 332.44 |
| Formula | C23H24O2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1010694-08-2 |
| PubChem ID | 25111943 |
| InChI Key | PMRFEKRJNZQOSY-UHFFFAOYSA-N |
| Smiles | CC1(C)C2=C(C=CC(C#CC3=CC(C(O)=O)=CC=C3)=C2)C(C)(C)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for EC 19
References for EC 19
References are publications that support the biological activity of the product.
Christie et al (2008) Synthesis and evaluation of synthetic retinoid derivatives as inducers of stem cell differentiation. Org.Biomol.Chem. 6 3497 PMID: 19082150
Clemens et al (2013) The action of all-trans-retinoic acid (ATRA) and synthetic retinoid analogues (EC19 and EC23) on human pluripotent stem cells differentiation investigated using single cell infrared microspectroscopy. Mol.Biosyst. 9 677 PMID: 23364809
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Keywords: EC 19, EC 19 supplier, EC19, synthetic, all-trans, retinoic, acid, receptors, ATRA, differentiation, stem, cells, retinoids, Retinoic, Acid, Receptors, Retinal, Stem, Cells, 5849, Tocris Bioscience
Citations for EC 19
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Currently there are no citations for EC 19.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Retinoid Receptors Scientific Review
Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.