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Submit ReviewWAY 252623
Description: Potent LXR agonist
Chemical Name: 2-[(2-Chloro-4-fluorophenyl)methyl]-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole
Purity: ≥98% (HPLC)
Biological Activity for WAY 252623
WAY 252623 is a potent LXR agonist (IC50 values are 24 and 179 nM for LXRβ and LXRα, respectively). Reduces total serum cholesterol and LDL cholesterol, and inhibits lesion growth in models of atherosclerosis. Increases ABCA1 and ABCG1 mRNA levels in rat peripheral blood cells. Orally bioavailable.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Compound Libraries for WAY 252623
WAY 252623 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for WAY 252623
| M. Wt | 422.78 |
| Formula | C21H12ClF5N2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 875787-07-8 |
| PubChem ID | 16734800 |
| InChI Key | KYWWJENKIMRJBI-UHFFFAOYSA-N |
| Smiles | ClC1=CC(F)=CC=C1CN2N=C3C(C(F)(F)F)=CC=CC3=C2C4=CC=C(F)C=C4 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for WAY 252623
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.28 | 100 | |
| ethanol | 42.28 | 100 |
Preparing Stock Solutions for WAY 252623
The following data is based on the product molecular weight 422.78. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.37 mL | 11.83 mL | 23.65 mL |
| 5 mM | 0.47 mL | 2.37 mL | 4.73 mL |
| 10 mM | 0.24 mL | 1.18 mL | 2.37 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.47 mL |
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Product Datasheets for WAY 252623
References for WAY 252623
References are publications that support the biological activity of the product.
DiBlasio-Smith et al (2008) Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells. J.Transl.Med. 6 PMID: 18925943
Quinet et al (2009) LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse. J.Lipid Res. 50 2358 PMID: 19318684
If you know of a relevant reference for WAY 252623, please let us know.
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Keywords: WAY 252623, WAY 252623 supplier, WAY252623, LXR, liver, X, receptor, alpha, beta, LXRa, LXRb, β, α, potent, agonists, agonism, orally, bioavailable, LXR-like, Receptors, 5951, Tocris Bioscience
Citations for WAY 252623
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