Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewFPR A14
Description: FPR agonist
Chemical Name: 1,3-Benzodioxolane-5-carboxylic acid 4'-benzyloxy-3'-methoxybenzylidene hydrazide
Purity: ≥99% (HPLC)
Biological Activity for FPR A14
Formyl peptide receptor (FPR) agonist that potently activates neutrophils in vitro (EC50 values are 42 and 630 nM for neutrophil chemotaxis and Ca2+ mobilization respectively). Induces dose-dependent differentiation of mouse neuroblastoma N2a cells.
Technical Data for FPR A14
| M. Wt | 404.42 |
| Formula | C23H20N2O5 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 329691-12-5 |
| PubChem ID | 5503194 |
| InChI Key | ULOKADSYVZOTTL-CFRMEGHHSA-N |
| Smiles | O=C(N/N=C\C3=CC=C(OCC4=CC=CC=C4)C(OC)=C3)C1=CC(OCO2)=C2C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for FPR A14
References for FPR A14
References are publications that support the biological activity of the product.
Schepetkin et al (2007) High-throughput screening for small molecule activators of neutrophils: Identification of novel N-formyl peptide receptor agonists. Mol.Pharmacol. 71 1061 PMID: 17229869
Cussell et al (2019) The formyl peptide receptor agonist FPRa14 induces differentiation of Neuro2a mouse neuroblastoma cells into multiple distinct morphologies which can be specifically inhibited with FPR antagonists and FPR knockdown using siRNA. PLoS One 14 e0217815 PMID: 31170199
View Related Products by Target
View Related Products by Product Action
Keywords: FPR A14, FPR A14 supplier, Formyl, peptide, FPR, agonists, FPRA14, receptors, Peptide, Receptors, Cancer, Stem, Cell, Differentiation, 2826, Tocris Bioscience
2 Citations for FPR A14
Citations are publications that use Tocris products. Selected citations for FPR A14 include:
Yan et al (2015) Stimulation of hepatocarcinogenesis by neutrophils upon induction of oncogenic kras expression in transgenic zebrafish. J Hepatol 63 420 PMID: 25828472
Cussell et al (2019) The formyl peptide receptor agonist FPRa14 induces differentiation of Neuro2a mouse neuroblastoma cells into multiple distinct morphologies which can be specifically inhibited with FPR antagonists and FPR knockdown using siRNA. PLoS One. 14 e0217815 PMID: 31170199
Reviews for FPR A14
There are currently no reviews for this product. Be the first to review FPR A14 and earn rewards!
Have you used FPR A14?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image