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Submit ReviewCabergoline
Description: D2-like agonist (D2>D3>D4)
Chemical Name: N-[3-(Dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)ergoline-8-carboxamide
Purity: ≥99% (HPLC)
Biological Activity for Cabergoline
Cabergoline is a selective D2-like dopamine receptor agonist (Ki values are 0.7, 1.5, 9.0 and 165 nM for D2, D3, D4 and D5 receptors respectively) that also displays high affinity for several serotonin receptor subtypes (Ki = 1.2 - 20.0 nM for 5-HT1A, 5-HT1D, 5-HT2A and 5-HT2B). Inhibits secretion of prolactin and growth hormone and reverses levodopa-induced dyskinesias in Parkinsonian monkeys.
Compound Libraries for Cabergoline
Cabergoline is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Cabergoline
| M. Wt | 451.6 |
| Formula | C26H37N5O2 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 81409-90-7 |
| PubChem ID | 90488776 |
| InChI Key | MNDMRWBGBXWMDE-YPAWHYETSA-N |
| Smiles | C=CCN1[C@]([C@]2([H])C[C@@H](C(N(C(NCC)=O)CCCN(C)C)=O)C1)([H])CC3=CNC4=CC=CC2=C43 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Cabergoline
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 45.16 | 100 | |
| ethanol | 45.16 | 100 |
Preparing Stock Solutions for Cabergoline
The following data is based on the product molecular weight 451.6. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.21 mL | 11.07 mL | 22.14 mL |
| 5 mM | 0.44 mL | 2.21 mL | 4.43 mL |
| 10 mM | 0.22 mL | 1.11 mL | 2.21 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
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Product Datasheets for Cabergoline
References for Cabergoline
References are publications that support the biological activity of the product.
Eguchi et al (1995) Effect of cabergoline, a DA agonist, on estrogen-induced rat pituitary tumors:in vitro culture studies. Endocr.J. 42 413 PMID: 7670571
Kvernmo et al (2006) A review of the receptor-binding and pharmacokinetic properties of DA agonists. Clin.Ther. 28 1065 PMID: 16982285
Hadj Tahar et al (2000) Sustained caberg. treatment reverses levodopa-induced dyskinesias in parkinsonian monkeys. Cin.Neuropharmacol. 23 195
If you know of a relevant reference for Cabergoline, please let us know.
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Keywords: Cabergoline, Cabergoline supplier, Selective, D2-like, agonists, Dopamine, Non-Selective, Receptors, dopaminergic, Non-selective, 2664, Tocris Bioscience
4 Citations for Cabergoline
Citations are publications that use Tocris products. Selected citations for Cabergoline include:
Lin et al (2015) Suppression of mTOR pathway and induction of autophagy-dependent cell death by caberg. PLoS One 6 39329 PMID: 26513171
Leng et al (2017) Activation of DRD5 inhibits tumor growth by autophagic cell death. Autophagy 13 1404 PMID: 28613975
Odaka et al (2014) Cabergoline, DA D2 receptor agonist, prevents neuronal cell death under oxidative stress via reducing excitotoxicity. J Biol Chem 9 e99271 PMID: 24914776
Gao et al (2017) Expression of Stem Cell Markers and DA D2 Receptors in Human and Rat Prolactinomas. Med Sci Monit 23 1827 PMID: 28411401
Do you know of a great paper that uses Cabergoline from Tocris? Please let us know.
Reviews for Cabergoline
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.