Home / Pharmacology / GPCRs / 7-TM Receptors / Dopamine Receptors / Non-selective Dopamine / Non-selective Dopamine Antagonists / Nemonapride

Nemonapride

Cat. No. 1746 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Highly potent D2-like antagonist; also 5-HT1A agonist
Alternative Names: YM 09151,YM 09151-2
Chemical Name: cis-5-Chloro-2-methoxy-4-(methylamino)-N-[2-methyl-1-(phenylmethyl)-3-pyrrolidinyl]benzamide
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Nemonapride

Nemonapride is a highly potent dopamine D2-like receptor antagonist; selective over D1-like receptors (Ki values are 0.1 and 740 nM for D2-like and D1-like receptors respectively). Also potent 5-HT1A receptor agonist (IC50 = 34 nM) and has affinity for sigma receptors.

Compound Libraries for Nemonapride

Nemonapride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Nemonapride

M. Wt 387.91
Formula C21H26ClN3O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 75272-39-8
PubChem ID 76968489
InChI Key QCYCDKUNJFKYEI-ZVWWNKPMSA-N
Smiles O=C(C3=C(OC)C=C(NC)C(Cl)=C3)N[C@@H]1CCN(CC2=CC=CC=C2)[C@@H]1C.O=C(C6=C(OC)C=C(NC)C(Cl)=C6)N[C@H]4CCN(CC5=CC=CC=C5)[C@H]4C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Nemonapride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 7.76 20
DMSO 9.7 25

Preparing Stock Solutions for Nemonapride

The following data is based on the product molecular weight 387.91. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 10.31 mL 51.56 mL 103.12 mL
1.25 mM 2.06 mL 10.31 mL 20.62 mL
2.5 mM 1.03 mL 5.16 mL 10.31 mL
12.5 mM 0.21 mL 1.03 mL 2.06 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for Nemonapride

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References for Nemonapride

References are publications that support the biological activity of the product.

Assie et al (1997) 5-HT1A receptor agonist properties of the antipsychotic, nemonapride: comparison with bromerguride and cloz. Eur.J.Pharmacol. 334 141 PMID: 9369342

Terai et al (1983) Selective binding of YM-09151-2, a new potent neuroleptic, to D2-DArgic receptors. Jpn.J.Pharmacol. 33 749 PMID: 6138453

Ujike et al (1996) [3H]YM-09151-2 (nemonapride), a potent radioligand for both sigma1 and sigma2 receptor subtypes. Neuroreport 7 1057 PMID: 8804051

If you know of a relevant reference for Nemonapride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Non-selective Dopamine Antagonists

Keywords: Nemonapride, Nemonapride supplier, 5-HT1A, agonists, potent, D2-like, dopamine, antagonists, Serotonin, Receptors, Non-Selective, dopaminergic, YM09151, YM09151-2, YM, 09151, 09151-2, Non-selective, Dopamine, 1746, Tocris Bioscience

1 Citation for Nemonapride

Citations are publications that use Tocris products. Selected citations for Nemonapride include:

Gadgaard & Jensen (2020) Functional characterization of 5-HT1A and 5-HT1B serotonin receptor signaling through G-protein-activated inwardly rectifying K+ channels in a fluorescence-based membrane potential assay Biochem Pharmacol 175 PMID: 32088264

Do you know of a great paper that uses Nemonapride from Tocris? Please let us know.

Reviews for Nemonapride

There are currently no reviews for this product. Be the first to review Nemonapride and earn rewards!

Have you used Nemonapride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Dopamine Receptors Scientific Review

Dopamine Receptors Scientific Review

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.