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Alcohol Dehydrogenases

Mammalian alcohol dehydrogenases are a family of enzymes which catalyze the oxidation of alcohols into aldehyde or ketones, with the aid of a co-enzyme, NAD+. In humans, there are five classes (I-V) of alcohol dehydrogenases, encoded by at least seven different genes.

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Mammalian alcohol dehydrogenases are a family of enzymes which catalyze the oxidation of alcohols into aldehyde or ketones, with the aid of a co-enzyme, NAD+. Members of this family also metabolize retinol and hydroxysteroids. In humans, there are five classes (I-V) of alcohol dehydrogenases, encoded by at least seven different genes. The primary hepatic enzyme is alcohol dehydrogenase 1, a class I enzyme, which has A, B and C subunits (encoded by the ADH1A, ADH1B and ADH1C genes respectively), and catalyzes the conversion of ethanol to acetaldehyde.

External sources of pharmacological information for Alcohol Dehydrogenases :

    Alcohol Dehydrogenase Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    ADH1A Human ADH1A NM_000667 M12963
    Mouse Adh1 NM_007409 P00329
    Rat Adh1 NM_019286 P06757
    ADH1B Human ADH1B NM_000668 AF153821
    ADH1C Human ADH1C NM_000669 M12272
    ADH4 Human ADH4 NM_000670 M15943
    Mouse Adh4 NM_011996 Q496S1
    Rat Adh4 NM_017270 Q64563
    ADH5 Human ADH5 NM_000671 M29872
    Mouse Adh5 NM_007410 Q6P513
    Rat Adh5 NM_001126120 P12711
    ADH6 Human ADH6 NM_000672 AK092768
    ADH7 Human ADH7 NM_000673 X76342
    Mouse Adh7 NM_009626 Q64437
    Rat Adh7 NM_134329 P41682