Bombesin Receptors

Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B (NMB) and GRP18-27 (neuromedin C). There are three subtypes of the bombesin receptor. BB₁ was previously known as the NMB receptor while BB₂ was previously known as the GRP receptor. BB₃ is designated an orphan receptor, however it has been shown to respond to NMB peptides, albeit at a lower potentcy than BB₁.

The receptors are G_q/11-coupled and are involved in the regulation of many biological functions including sensory transmission, thermoregulation, feeding and pituitary, gastric and pancreatic secretion. They may also be involved in tissue development, proliferation and differentiation.

External sources of pharmacological information for Bombesin Receptors :

• IUPHAR Receptor Code

• BJP Guide

Literature for Bombesin Receptors

Tocris offers the following scientific literature for Bombesin Receptors to showcase our products. We invite you to request* your copy today!

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Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

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Bombesin Receptor Gene Data