Bombesin Receptors
Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B (NMB) and GRP18-27 (neuromedin C). Three subtypes of bombesin receptor are known: BB1, BB2 and an orphan receptor (bb3).
Bombesin Receptor Agonists |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 1789 | GRP (human) |
| Endogenous GRP receptor agonist | |
Bombesin Receptor Antagonists |
|
| Cat. No. | Product Name / Activity |
| 2602 | PD 176252 |
| GRP (BB2) and NMB (BB1) receptor antagonist | |
Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B (NMB) and GRP18-27 (neuromedin C). There are three subtypes of the bombesin receptor. BB1 was previously known as the NMB receptor while BB2 was previously known as the GRP receptor. BB3 is designated an orphan receptor, however it has been shown to respond to NMB peptides, albeit at a lower potentcy than BB1.
The receptors are Gq/11-coupled and are involved in the regulation of many biological functions including sensory transmission, thermoregulation, feeding and pituitary, gastric and pancreatic secretion. They may also be involved in tissue development, proliferation and differentiation.
External sources of pharmacological information for Bombesin Receptors :
Literature for Bombesin Receptors
Tocris offers the following scientific literature for Bombesin Receptors to showcase our products. We invite you to request* your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Bombesin Receptor Gene Data
| Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
|---|---|---|---|---|
| BB1 | Human | NMBR | NM_002511 | P28336 |
| Mouse | Nmbr | NM_008703 | O54799 | |
| Rat | Nmbr | NM_012799 | P24053 | |
| BB2 | Human | GRPR | NM_005314 | P30550 |
| Mouse | Grpr | NM_008177 | P21729 | |
| Rat | Grpr | NM_012706 | P52500 | |
| bb3 | Human | BRS3 | NM_001727 | P32247 |
| Mouse | Brs3 | NM_009766 | O54798 | |
| Rat | Brs3 | NM_152845 | Q8K418 |
Our Peptides Involved in Appetite Modulation review gives an overview of the peptides implicated in appetite regulation and energy homeostasis.
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