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Exonucleases

Exonucleases, also known as restriction enzymes, are a group of esterases that cleave nucleotides from RNA or DNA chains by hydrolyzing the phosphodiester bonds at either the 3' or 5' terminus. Exonucleases can exist individually or as part of a larger complex.

Products
Background
Gene Data

Exonuclease Inhibitors
Cat. No. Product Name / Activity
3190 Mirin
Inhibitor of MRN exonuclease activity

Related Targets

Exonucleases, also known as restriction enzymes, are a group of esterases that cleave nucleotides from RNA or DNA chains by hydrolyzing the phosphodiester bonds at either the 3' or 5' terminus. Exonucleases can exist individually, for example RNase D, or as part of a larger complex, for example Mre11 exists in a multimeric complex with Rad50 and Nbs1. Exonucleases are nuclear enzymes and are vital for DNA synthesis, proofreading and repair.

External sources of pharmacological information for Exonucleases :

    Exonuclease Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    Mre11 Human MRE11A NM_005591 P49959
    Mouse Mre11a NM_018736 Q61216
    Rat Mre11a NM_022279 Q9JIM0
    ERI1 Human ERI1 NM_153332 Q8IV48
    Mouse Thex1 NM_026067 Q7TMF2
    Rat Thex1 NM_001014143 Q5FVR4
    ERI2 Human ERI2 NM_080663 A8K979
    ERI3 Human ERI3 NM_024066 O43414
    Mouse Prnpip1 NM_080469 Q8C460
    EXO1 Human EXO1 NM_006027 Q9UQ84
    Mouse Exo1 NM_012012 Q9QZ11
    Rat Exo1 NM_001107198 XP_222932
    XRN1 Human XRN1 NM_019001 Q8IZH2
    Mouse Xrn1 NM_011916 P97789
    Rat Xrn1 XM_217233 XP_217233