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10Panx

Cat. No. 3348 8 Citations Submit a Review Datasheet / COA / SDS
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Description: Panx-1 mimetic inhibitory peptide; blocks pannexin-1 gap junctions
Purity: ≥95% (HPLC)
Datasheet
Citations (8)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for 10Panx

10Panx is a panx-1 mimetic inhibitory peptide that blocks pannexin-1 gap junctions. Inhibits P2X7-mediated dye uptake, ATP-mediated IL-1β release and caspase-1 activation without altering membrane current in macrophages in vitro. Also blocks activation of NMDA receptor secondary currents (I2nd) by > 70%.

Technical Data for 10Panx

M. Wt 1242.37
Formula C58H79N15O16
Sequence WRQAAFVDSY
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 955091-53-9
PubChem ID 44233736
InChI Key JCJASTVQGSKHKZ-QZHJRRRASA-N
Smiles [H]N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 10Panx

Solubility Soluble to 1 mg/ml in water

Product Datasheets for 10Panx

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for 10Panx

References are publications that support the biological activity of the product.

Pelegrin and Surprenant (2006) Pannexin-1 mediates large pore formation and interleukin-1β; release by the ATP-gated P2X7 receptor. EMBO J. 25 5071 PMID: 17036048

Wang et al (2007) Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters. Am.J.Physiol.Cell Physiol. 293 C1112 PMID: 17652431

Thompson et al (2008) Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus. Science 322 1555 PMID: 19056988

If you know of a relevant reference for 10Panx, please let us know.

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Keywords: 10Panx, 10Panx supplier, Panx-1, mimetic, inhibitory, peptide, blocks, pannexin-1, gap, junctions, Connexins, Channels, modulators, Gap, 3348, Tocris Bioscience

8 Citations for 10Panx

Citations are publications that use Tocris products. Selected citations for 10Panx include:

Adamczyk et al (2015) P2X7 receptor activation regulates rapid unconventional export of transglutaminase-2. J Cell Sci 128 4615 PMID: 26542019

Chen et al (2019) Enhanced Macrophage Pannexin 1 Expression and Hemichannel Activation Exacerbates Lethal Experimental Sepsis. Sci Rep 9 160 PMID: 30655582

Hudson et al (2019) Pregnane X Receptor Activation Triggers Rapid ATP Release in Primed Macrophages That Mediates NLRP3 Inflammasome Activation. J Pharmacol Exp Ther 370 44 PMID: 31004077

Albalawi et al (2017) The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain. Front Cell Neurosci 11 227 PMID: 28848393

Do you know of a great paper that uses 10Panx from Tocris? Please let us know.

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