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Description: Antagonist of neurosteroid potentiation and direct gating of GABAA
Chemical Name: 17-Phenyl-(3α,5α)-androst-16-en-3-ol
Purity: ≥99% (HPLC)
Biological Activity for 17-PA
17-PA is a selective antagonist of neurosteroid potentiation and direct gating of GABAA receptors. Selectively reduces the effects of 5α-reduced steroids compared to 5β-reduced steroids and displays no effect on potentiation evoked by barbiturates and benzodiazepines. Attenuates 3α,5α-THP-induced loss of righting reflex and total sleep time following i.c.v administration in rats.
Technical Data for 17-PA
| M. Wt | 350.54 |
| Formula | C25H34O |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 694438-95-4 |
| PubChem ID | 25068278 |
| InChI Key | SINAMTXBCYKFDL-WBJZGETLSA-N |
| Smiles | O[C@@H]1CC[C@@]2(C)[C@](CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC=C4C5=CC=CC=C5)([H])C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for 17-PA
References for 17-PA
References are publications that support the biological activity of the product.
Mennerick et al (2004) Selective antagonism of 5α-reduced neurosteroid effects at GABAA receptors. Mol.Pharmacol. 65 1191 PMID: 15102947
Akk et al (2007) Ethanol modulates the interaction of the endogenous neurosteroid allopregnanolone with the α1β2γ2L GABAA receptor. Mol.Pharmacol. 71 461 PMID: 17105870
Kelley et al (2007) Antagonism of neurosteroid modulaton of native γ-aminobutyric acid receptors by (3α,5α)-17-phenylandrost-16-en-3-ol. Eur.J.Pharmacol. 572 94 PMID: 17658511
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Keywords: 17-PA, 17-PA supplier, antagonists, neurosteroid, potentiation, direct, gating, GABAA, Receptors, 2681, Tocris Bioscience
Citations for 17-PA
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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