Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit Review193 D7 New
Description: JMJD1C inhibitor
Chemical Name: 8-Benzoyl-2,3,6,7-tetrahydro-5-oxo-5H-thiazolo[3,2-a]pyridine-6-acetic acid
Purity: ≥98% (HPLC)
Biological Activity for 193 D7
193 D7 is a histone demethylase JMJD1C inhibitor (IC50 = 0.59 μM in in vitro demethylation assay). In vivo, 193 D7 suppresses tumor by targeting intratumoral Treg cells in mice tumor models. 193 D7 is orally bioavailable.
Technical Data for 193 D7
| M. Wt | 317.36 |
| Formula | C16H15NO4S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 861224-48-8 |
| PubChem ID | 12182298 |
| InChI Key | DZLRINQZFUBGSQ-UHFFFAOYSA-N |
| Smiles | O=C(CC1C(N2C(SCC2)=C(C1)C(C3=CC=CC=C3)=O)=O)O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for 193 D7
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.74 | 100 | |
| ethanol | 6.35 | 20 |
Preparing Stock Solutions for 193 D7
The following data is based on the product molecular weight 317.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.15 mL | 15.75 mL | 31.51 mL |
| 5 mM | 0.63 mL | 3.15 mL | 6.3 mL |
| 10 mM | 0.32 mL | 1.58 mL | 3.15 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.63 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for 193 D7
References for 193 D7
References are publications that support the biological activity of the product.
Long et al (2024) Targeting JMJD1C to selectively disrupt tumor Treg cell fitness enhances antitumor immunity. Nat.Immunol. 25 525 PMID: 38356061
If you know of a relevant reference for 193 D7, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: 193 D7, 193 D7 supplier, 193D7, histone, demethylases, inhibits, inhibitors, JMJD1C, KDM3C, selective, antiproliferative, orally, bioavailable, in, vivo, Histone, Demethylases, 8167, Tocris Bioscience
Citations for 193 D7
Citations are publications that use Tocris products.
Currently there are no citations for 193 D7. Do you know of a great paper that uses 193 D7 from Tocris? Please let us know.
Reviews for 193 D7
There are currently no reviews for this product. Be the first to review 193 D7 and earn rewards!
Have you used 193 D7?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.