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Submit Review(1S,3R)-ACPD
Discontinued Product
0284 has been discontinued.
View all Glutamate (Metabotropic) Group I Receptors products.
Description: Group I and group II mGlu agonist; active isomer of (±)-trans-ACPD (Cat. No. 0187)
Chemical Name: (1S,3R)-1-Aminocyclopentane-1,3-dicarboxylic acid
Purity: ≥98% (HPLC)
Biological Activity for (1S,3R)-ACPD
(1S,3R)-ACPD is an active isomer of (±)-trans-ACPD. Agonist at both group I and II mGlu receptors (EC50 values are 5, 15, 42 and 60 μM at mGluR2, mGluR5, mGluR1 and mGluR6 respectively).
NPEC-caged-(1S,3R)-ACPD, (±)-trans-ACPD and cis-ACPD also available.
Technical Data for (1S,3R)-ACPD
| M. Wt | 173.17 |
| Formula | C7H11NO4 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 111900-32-4 |
| PubChem ID | 104766 |
| InChI Key | YFYNOWXBIBKGHB-FBCQKBJTSA-N |
| Smiles | N[C@]1([C@@](O)=O)C[C@]([H])([C@](O)=O)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for (1S,3R)-ACPD
References for (1S,3R)-ACPD
References are publications that support the biological activity of the product.
Conti et al (2002) Synthesis and pharmacology of 3-hydroxy-Δ2-isoxazoline-cyclopentance analogues of glutamic acid. Farmaco 57 889 PMID: 12484537
Knopfel et al (1995) Metabotropic glutamate receptors: novel targets for drug development. J.Med.Chem. 38 1417 PMID: 7738999
Mistry and Challis (1996) Differences in agonist and antagonist activities for two indicies of metabotropic glutamate receptor-stimulated phosphoinositide turnover. Br.J.Pharmacol. 117 1735 PMID: 8732284
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Keywords: (1S,3R)-ACPD, (1S,3R)-ACPD supplier, Group, II, group, I, mGlur, agonists, Receptors, mGlu2, mGlu3, mGluR2, mGluR3, Glutamate, Metabotropic, mGlu1, mGlu5, mGluR1, mGluR5, (Metabotropic), 0284, Tocris Bioscience
6 Citations for (1S,3R)-ACPD
Citations are publications that use Tocris products. Selected citations for (1S,3R)-ACPD include:
Scholler (2017) HTS-compatible FRET-based conformational sensors clarify membrane receptor activation. Nat Chem Biol 13 372 PMID: 28135236
Andlauer et al (2014) Drep-2 is a novel synaptic protein important for learning and memory. J Neurosci 3 PMID: 25392983
Blanco et al (2008) Tone-dependent vascular responses to astrocyte-derived signals. Am J Physiol Heart Circ Physiol 294 H2855 PMID: 18456724
Pasquale and Sherman (2013) A modulatory effect of the feedback from higher visual areas to V1 in the mouse. J Neurophysiol 109 2618 PMID: 23446698
Tang et al (2015) Stimulation-evoked Ca2+ signals in astrocytic processes at hippocampal CA3-CA1 synapses of adult mice are modulated by glutamate and ATP. J Neurosci 35 3016 PMID: 25698739
Yamada et al (2008) Long-range axonal calcium sweep induces axon retraction. Sci Adv 28 4613 PMID: 18448637
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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