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Submit Review2',3'-cGAMP sodium salt
Description: Endogenous high affinity STING agonist
Chemical Name: 2',3'-Cyclic guanosine monophosphate-adenosine monophosphate sodium salt
Purity: ≥98% (HPLC)
Biological Activity for 2',3'-cGAMP sodium salt
2',3'-cGAMP sodium salt is a endogenous high affinity STING agonist (Kd values are 3.79 and 120 nM for human and rat STING, respectively). Induces repolarization of M2 macrophages in vitro.
This product is sold in units of 359μg, equivalent to 0.5μmol.
Technical Data for 2',3'-cGAMP sodium salt
| M. Wt | 718.37 |
| Formula | C20H22N10Na2O13P2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2734858-36-5 |
| PubChem ID | 71563406 |
| InChI Key | XRILCFTWUCUKJR-INFSMZHSSA-N |
| Smiles | [H][C@]12COP(O[C@]3([C@H]([C@H](N4C=NC5=C(N=CN=C45)N)O[C@@]3(COP(O[C@@]([C@H](N6C=NC7=C6N=C(NC7=O)N)O1)([C@@H]2O)[H])(O[Na])=O)[H])O)[H])(O[Na])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for 2',3'-cGAMP sodium salt
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 35.92 | 50 |
Preparing Stock Solutions for 2',3'-cGAMP sodium salt
The following data is based on the product molecular weight 718.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 2.78 mL | 13.92 mL | 27.84 mL |
| 2.5 mM | 0.56 mL | 2.78 mL | 5.57 mL |
| 5 mM | 0.28 mL | 1.39 mL | 2.78 mL |
| 25 mM | 0.06 mL | 0.28 mL | 0.56 mL |
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Product Datasheets for 2',3'-cGAMP sodium salt
References for 2',3'-cGAMP sodium salt
References are publications that support the biological activity of the product.
Zhang et al (2013) Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol.Cell. 51 226 PMID: 23747010
Downey et al (2014) DMXAA causes tumor site-specific vascular disruption in murine non-small cell lung cancer, and like the endogenous non-canonical cyclic dinucleotide STING agonist, 2'3'-cGAMP, induces M2 macrophage repolarization. PLoS One 9 e99988 PMID: 24940883
Zhang et al (2015) Rat and human STINGs profile similarly towards anticancer/antiviral compounds. Sci.Rep. 5 18035 PMID: 26669264
If you know of a relevant reference for 2',3'-cGAMP sodium salt, please let us know.
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Keywords: 2',3'-cGAMP sodium salt, 2',3'-cGAMP sodium salt supplier, endogenous, high, affinity, STING, agonists, STING-Dependent, Signaling, 5945, Tocris Bioscience
Citations for 2',3'-cGAMP sodium salt
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