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Submit Review2,4-Diamino-6-hydroxypyrimidine
Description: Inhibits tetrahydrobiopterin synthesis and thus NOS activity
Purity: ≥99% (HPLC)
Biological Activity for 2,4-Diamino-6-hydroxypyrimidine
2,4-Diamino-6-hydroxypyrimidine is a GTP cyclohydrolase I (GCH1) inhibitor. Prevents the de novo synthesis of tetrahydrobiopterin (BH4) and thus suppresses the activity of NO synthase. Exhibits more potent inhibition of GCH1 in the presence of GFRP (GTP cyclohydrolase feedback-regulatory protein).
Technical Data for 2,4-Diamino-6-hydroxypyrimidine
| M. Wt | 126.12 |
| Formula | C4H6N4O |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 56-06-4 |
| PubChem ID | 2944 |
| InChI Key | SWELIMKTDYHAOY-UHFFFAOYSA-N |
| Smiles | NC1=NC(N)=NC(O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for 2,4-Diamino-6-hydroxypyrimidine
References for 2,4-Diamino-6-hydroxypyrimidine
References are publications that support the biological activity of the product.
Moore and Handy (1997) Selective inhibitors of neuronal nitric oxide synthase - is no NOS really good NOS for the nervous system? TiPs 18 204 PMID: 9226999
Werner-Felmayer et al (1993) Pteridine biosynthesis in human endothelial cells. Impact of NO-mediated formation of cyclic GMP. J.Biol.Chem. 268 1842 PMID: 7678411
Xie et al (1998) GTP cyclohydrolase I inhibition by the prototypic inhibitor 2,4-diamino-6-hydroxypyrimidine. J.Biol.Chem. 273 21091 PMID: 9694862
Charles et al (2019) Pharmacological inhibition of guanosine triphosphate cyclohydrolase1 elevates tyrosine phosphorylation of caveolin1 and cellular senescence. Eur.J.Pharmacol. 848 1 PMID: 30690003
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Keywords: 2,4-Diamino-6-hydroxypyrimidine, 2,4-Diamino-6-hydroxypyrimidine supplier, GTP, cyclohydrolase, I, inhibitor, GCH1, GTPCH, GCH, inhibitors, inhibits, biosynthesis, tetrahydrobiopterin, BH4, NOS, Nitric, Oxide, synthase, Signaling, Signalling, Other, Hydrolases, 0476, Tocris Bioscience
Citations for 2,4-Diamino-6-hydroxypyrimidine
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