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Submit Review2-Phospho-L-ascorbic acid trisodium salt
Description: Ascorbic acid derivative; maintains differentiation potential in bone marrow-derived MSCs
Chemical Name: 2-(Dihydrogen phosphate)-L-ascorbic acid sodium salt
Purity: ≥95% (HPLC)
Biological Activity
2-Phospho-L-ascorbic acid trisodium salt is a stable ascorbic acid derivative used in cell culture; in combination with FGF-2, maintains differentiation potential in bone marrow-derived mesenchymal stem cells (MSC) through increased expression of HGF. Also exhibits synergistic protection of hMSCs under oxidative stress in combination with N-acetylcysteine (Cat. No. 5619).
Technical Data
| M. Wt | 322.05 |
| Formula | C6H6Na3O9P |
| Storage | Desiccate at RT |
| Purity | ≥95% (HPLC) |
| CAS Number | 66170-10-3 |
| PubChem ID | 10990876 |
| InChI Key | VWCFDYSMDMCPLU-OFBPEYICSA-K |
| Smiles | [O-]C([C@]([C@@H](O)CO)([H])O1)=C(OP([O-])([O-])=O)C1=O.[Na+].[Na+].[Na+] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 32.2 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 322.05. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.11 mL | 15.53 mL | 31.05 mL |
| 5 mM | 0.62 mL | 3.11 mL | 6.21 mL |
| 10 mM | 0.31 mL | 1.55 mL | 3.11 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
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References
References are publications that support the biological activity of the product.
Falcon et al (2014) An in vitro cord formation assay identifies unique vascular phenotypes associated with angiogenic growth factors. PLoS One 9 e106901 PMID: 25210890
Bae et al (2015) L-ascorbic acid 2-phosphate and fibroblast growth factor-2 treatment maintains differentiation potential in bone marrow-derived mesenchymal stem cells through expression of hepatocyte growth factor. Growth Factors 33 71 PMID: 25714612
Li et al (2015) Synergistic protection of N-acetylcysteine and ascorbic acid 2-phosphate on human mesenchymal stem cells against mitoptosis, necroptosis and apoptosis. Sci.Rep. 5 9819 PMID: 25909282
If you know of a relevant reference for 2-Phospho-L-ascorbic acid trisodium salt, please let us know.
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